Reactome | FBXL15 [cytosol]

FBXL15 [cytosol]

Stable Identifier

R-GGA-8862625

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

F1NF36

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Neddylation (Gallus gallus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
        
        CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXL15 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NF36

Reference Genes

BioGPS Gene:428951

dbSNP Gene:428951

ENSEMBL:ENSGALG00000005684

KEGG Gene (Gallus gallus):428951

Monarch:428951

NCBI Gene:428951

Reference Transcript

Other Identifiers

428951

ENSGALG00000005684

ENSGALP00000009102

ENSGALT00000009116

EntrezGene:428951

EntrezGene:FBXL15

FBXL15

FBXL15-201

GgaAffx.26562.1.S1_at

GO:0000086

GO:0000278

GO:0003674

GO:0004842

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0006464

GO:0006511

GO:0007049

GO:0007165

GO:0008150

GO:0009056

GO:0009058

GO:0016567

GO:0019005

GO:0030513

GO:0031146

GO:0032991

GO:0034641

GT_A_87_P080546

HGNC:28155

IPR006553

IPR032675

SM00367

UPI00035054D2

XM_015288465

XM_015288466

XM_015288467

XP_015143951

XP_015143952

XP_015143953

Participant Of

hasMember

F-box protein [cytosol]

Inferred From

FBXL15 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015143952.1, XP_015143951.1