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SOCS3 [cytosol]
Stable Identifier
R-GGA-873794
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
SOCS3, R4GJH9
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Polyubiquitination of substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Release of E3 from polyubiquitinated substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon alpha/beta signaling (Gallus gallus)
Activation of JAK kinases (Gallus gallus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Interferon gamma signaling (Gallus gallus)
Regulation of IFNG signaling (Gallus gallus)
SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Transphosphorylation of JAK1 (Gallus gallus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-6 family signaling (Gallus gallus)
Interleukin-6 signaling (Gallus gallus)
SOCS3 binds IL6ST (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Neddylation (Gallus gallus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
NEDD8-CRL5 E3 ligase [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
CRL5 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
NEDD8-CRL5 E3 ligase [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Gallus gallus)
SOCS3 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:R4GJH9
Gene Names
SOCS3
Reference Genes
ENSEMBL:ENSGALG00000027786
ENSEMBL:ENSGALG00010029295.1 SOCS3
Other Identifiers
395299
GO:0001784
GO:0001932
GO:0003723
GO:0005886
GO:0005942
GO:0006629
GO:0006954
GO:0007165
GO:0009898
GO:0009968
GO:0023052
GO:0030154
GO:0030292
GO:0035198
GO:0035556
GO:0036211
GO:0042532
GO:0045597
GO:0046426
GO:0046627
GO:0046854
GO:0046935
GO:0050728
GO:0097398
GO:0098772
GO:0110165
GO:1990830
GT_A_87_P037625
GT_A_87_P129278
Gga.915.1.S1_at
Participates
as a member of
CUL5-box protein [cytosol] (Gallus gallus)
SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
as an input of
SOCS3 binds IL6ST (Gallus gallus)
as a component of
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Gallus gallus)
Inferred From
SOCS3 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000184557
Ensembl
ENSGALT00010070846
,
ENSGALP00010043537
,
ENSGALG00010029295
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