Reactome | Ghost homologue of RPL18 [cytosol]

Ghost homologue of RPL18 [cytosol]

Stable Identifier

R-GGA-72420

Type

Genes and Transcripts [GenomeEncodedEntity]

Species

Gallus gallus

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of RNA (Gallus gallus)

- Nonsense-Mediated Decay (NMD) (Gallus gallus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Gallus gallus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        Ghost homologue of RPL18 [cytosol] (Gallus gallus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        Ghost homologue of RPL18 [cytosol] (Gallus gallus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        Ghost homologue of RPL18 [cytosol] (Gallus gallus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Gallus gallus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        Ghost homologue of RPL18 [cytosol] (Gallus gallus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        60S ribosomal complex [cytosol] (Gallus gallus)
        
        Ghost homologue of RPL18 [cytosol] (Gallus gallus)

Participates

as a component of

Inferred From

RPL18 [cytosol] (Homo sapiens)