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PDPK1 [plasma membrane]
Stable Identifier
R-GGA-61459
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
Q5F3U4
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
Regulation of TP53 Activity (Gallus gallus)
Regulation of TP53 Expression and Degradation (Gallus gallus)
Regulation of TP53 Degradation (Gallus gallus)
PDPK1 phosphorylates SGK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)
AKT1/PDK1 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
AKT binds PDPK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Activation of TAK1-TAB2 complex (Gallus gallus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Gallus gallus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Interaction of Bcl10 to CARMA1 (Gallus gallus)
Bcl10 bound to CARMA1 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Oligomerization of Bcl10 (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Oligomerization of CARMA1 (Gallus gallus)
Activated CARMA1 [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Phosphorylation of Bcl10 (Gallus gallus)
Bcl10 bound to CARMA1 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Translocation of CARMA1 to Plasma membrane (Gallus gallus)
CARMA1 bound to PDK1 [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Translocation of PDK1 to Plasma membrane (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Translocation of TRAF6 to CBM complex (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Gallus gallus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Gallus gallus)
CARMA1 trimer [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Innate Immune System (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
Translocation of PDK1 to Plasma membrane (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)
AKT1/PDK1 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
AKT binds PDPK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1 binds PIP2 (Gallus gallus)
PDPK1:PIP2 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1 phosphorylates SGK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through PI3Kgamma (Gallus gallus)
PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)
PDK1:AKT:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
Estrogen-stimulated signaling through PRKCZ (Gallus gallus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Gallus gallus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
Activation of AKT2 (Gallus gallus)
PDPK1 binds PIP3 (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
Activation of AKT2 (Gallus gallus)
PDPK1 binds PIP3 (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFR2 mediated cell proliferation (Gallus gallus)
PDK1 phosphorylates PKC (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT binds PDPK1 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
PIP3 recruits PDPK1 to the membrane (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases activate PKNs (Gallus gallus)
PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
PDPK1 [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q5F3U4
Reference Genes
BioGPS Gene:416588
ENSEMBL:ENSGALG00000006418
KEGG Gene (Gallus gallus):416588
Monarch:416588
NCBI Gene:416588
Reference Transcript
RefSeq:NM_001012529.1
Participates
as a member of
AKT1/PDK1 [plasma membrane] (Gallus gallus)
as a component of
PDK1:AKT:PIP3 [plasma membrane] (Gallus gallus)
PDK1:PIP2,PIP3 [plasma membrane] (Gallus gallus)
PDPK1:PIP2 [plasma membrane] (Gallus gallus)
PDPK1:PIP3 [plasma membrane] (Gallus gallus)
as an input of
PDPK1 binds PIP3 (Gallus gallus)
Other forms of this molecule
PDPK1 [cytosol]
Inferred From
PDPK1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001012547.1
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