Reactome | PRKCA [cytosol]

PRKCA [cytosol]

Stable Identifier

R-GGA-58196

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

R4GHL2

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Gallus gallus)

- Non-integrin membrane-ECM interactions (Gallus gallus)
  - Syndecan interactions (Gallus gallus)
    - Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)
      - Protein Kinase C, alpha type: DAG [plasma membrane] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)
      - Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Gallus gallus)
        
        Protein Kinase C, alpha type: DAG [plasma membrane] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - DAG and IP3 signaling (Gallus gallus)
    - CaM pathway (Gallus gallus)
      - Calmodulin induced events (Gallus gallus)
        
        PKC phosphorylates GRK2 (Gallus gallus)
        
        active PKC (alpha, gamma, delta) [cytosol] (Gallus gallus)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)
- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (i) signalling events (Gallus gallus)
      - Opioid Signalling (Gallus gallus)
        
        G-protein mediated events (Gallus gallus)
        
        PLC beta mediated events (Gallus gallus)
        
        Ca-dependent events (Gallus gallus)
        
        CaM pathway (Gallus gallus)
        
        Calmodulin induced events (Gallus gallus)
        
        PKC phosphorylates GRK2 (Gallus gallus)
        
        active PKC (alpha, gamma, delta) [cytosol] (Gallus gallus)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Gallus gallus)
        
        EGFR Transactivation by Gastrin (Gallus gallus)
        
        Activated PKC-alpha activate MMP3 (Gallus gallus)
        
        Protein Kinase C, alpha type: DAG [plasma membrane] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)
        
        Diacylgycerol activates Protein kinase C, alpha type (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)
        
        Protein Kinase C, alpha type: DAG [plasma membrane] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - VEGFR2 mediated cell proliferation (Gallus gallus)
        
        PDK1 phosphorylates PKC (Gallus gallus)
        
        PKCA,PKCB,PKCD,PKCZ [cytosol] (Gallus gallus)
        
        PRKCA [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:R4GHL2

Reference Genes

BioGPS Gene:417430

ENSEMBL:ENSGALG00000025950

Monarch:417430

NCBI Gene:417430

Reference Transcript

RefSeq:XM_004946229.2

Other Identifiers

04070+2.7.11.13

417430

AC157953

AC161467

ENSGALG00000025950

ENSGALP00000041561

ENSGALT00000045861

EntrezGene:417430

EntrezGene:PRKCA

EntrezGene:PRKCA-202

GgaAffx.20127.1.S1_s_at

GO:0000166

GO:0000278

GO:0001938

GO:0002159

GO:0003674

GO:0004672

GO:0004674

GO:0004697

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006950

GO:0007049

GO:0007155

GO:0007165

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0010595

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019899

GO:0022607

GO:0030335

GO:0031666

GO:0034330

GO:0034351

GO:0035403

GO:0035408

GO:0035556

GO:0040011

GO:0043167

GO:0043226

GO:0043536

GO:0045766

GO:0045785

GO:0045931

GO:0046872

GO:0048646

GO:0048856

GO:0048870

GO:0051276

GO:0070555

GO:0090330

IPR000008

IPR000719

IPR000961

IPR002219

IPR008271

IPR011009

IPR014375

IPR017441

IPR017892

IPR020454

IPR034663

IPR035892

PF00069

PF00130

PF00168

PF00433

PR00008

PR00360

PRKCA

Q5F3X1

SM00109

SM00133

SM00220

SM00239

UPI000350383F

XM_004946229

XM_025141605

XP_004946286

XP_024997373

Participant Of

hasMember

input

Diacylgycerol activates Protein kinase C, alpha type

hasComponent

Protein Kinase C, alpha type: DAG [plasma membrane]

Other forms of this molecule

PRKCA [nucleoplasm]

PRKCA [plasma membrane]

phospho-pT497,T638,S657-PRKCA [plasma membrane]

phospho-p-T497,T638,S657-PRKCA [cytosol]

phospho-p-T497-PRKCA [cytosol]

phospho-p-T497,T638,S657-PRKCA [nucleoplasm]

Inferred From

PRKCA [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_004946286.1