Reactome | phospho-p-6Y,S732-PTK2 [cytosol]

phospho-p-6Y,S732-PTK2 [cytosol]

Stable Identifier

R-GGA-5218694

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

Q00944

Locations in the PathwayBrowser

Expand all

Signal Transduction (Gallus gallus)

- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - CRK binds BCAR1 and or PXN (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
        
        phospho-p-6Y,S732-PTK2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
        
        phospho-p-6Y,S732-PTK2 [cytosol] (Gallus gallus)
      - DOCK180:ELMO binds CRK (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
        
        phospho-p-6Y,S732-PTK2 [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
        
        phospho-p-6Y,S732-PTK2 [cytosol] (Gallus gallus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
        
        phospho-p-6Y,S732-PTK2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q00944

Reference Genes

BioGPS Gene:396416

dbSNP Gene:396416

ENSEMBL:ENSGALG00000031741

KEGG Gene (Gallus gallus):396416

Monarch:396416

NCBI Gene:396416

Reference Transcript

RefSeq:NM_205435.1

Other Identifiers

04660+2.7.10.2

1KTM

1PV3

1QVX

2AEH

2AL6

2J0J

2J0K

2J0L

2J0M

2JKK

2JKM

2JKO

2JKQ

2L6F

2L6G

2L6H

396416

3ZDT

4BRX

4C7T

4CYE

4D4R

4D4S

4D4V

4D4Y

4D55

4D58

4D5H

4D5K

A0A1L1RJ83

AAA48765

AAA48766

ENSGALG00000031741

ENSGALP00000044406

ENSGALT00000072414

EntrezGene:396416

EntrezGene:PTK2

EntrezGene:PTK2-202

Gga.15614.1.S1_a_at

Gga.15614.1.S2_a_at

Gga.4725.1.S1_at

GO:0000166

GO:0001525

GO:0002020

GO:0003674

GO:0004198

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005815

GO:0005856

GO:0005886

GO:0005925

GO:0006464

GO:0006468

GO:0006508

GO:0006950

GO:0007010

GO:0007015

GO:0007155

GO:0007165

GO:0007172

GO:0007173

GO:0007275

GO:0008150

GO:0008219

GO:0008233

GO:0008283

GO:0008284

GO:0009268

GO:0010812

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0021852

GO:0022607

GO:0030054

GO:0030154

GO:0030155

GO:0031953

GO:0032092

GO:0034330

GO:0035994

GO:0038083

GO:0040011

GO:0042127

GO:0042383

GO:0042802

GO:0043167

GO:0043197

GO:0043226

GO:0044319

GO:0046777

GO:0048471

GO:0048646

GO:0048856

GO:0048870

GO:0051894

GO:0060055

GO:0061098

GO:0065003

GO:1904237

GO:2000811

GT_A_87_P057091

GT_A_87_P105323

GT_A_87_P105328

GT_A_87_P122603

IPR000299

IPR000719

IPR001245

IPR005189

IPR008266

IPR011009

IPR011993

IPR014352

IPR017441

IPR019748

IPR019749

IPR020635

IPR029071

IPR035963

IPR036137

IPR041390

IPR041784

L08402

M86656

NM_205435

NP_990766

PF00373

PF03623

PF07714

PF18038

PR00109

PTK2

SM00219

SM00295

UPI000012A4FA

Participant Of

hasComponent

VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane]

Other forms of this molecule

phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

phospho-p-Y194,Y397-PTK2 [cytosol]

phospho-pY-PTK2 [cytosol]

phospho-p-5Y-PTK2 [cytosol]

phospho-p-5Y,S732-PTK2 [cytosol]

phospho-p-Y397-PTK2 [cytosol]

PTK2 [cytosol]

PTK2(1-772) [cytosol]

PTK2(773-1052) [cytosol]

Inferred From

p-6Y,S732-PTK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397 (in Homo sapiens)

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 576 (in Homo sapiens)

Coordinate

576

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 577 (in Homo sapiens)

Coordinate

577

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 861 (in Homo sapiens)

Coordinate

861

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 925 (in Homo sapiens)

Coordinate

925

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 407 (in Homo sapiens)

Coordinate

407

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 732 (in Homo sapiens)

Coordinate

732

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_990766.1

PRO

Q00944

PDB

1PV3, 3ZDT, 4D4R, 2JKQ, 2L6G, 4D4S, 2L6H, 4CYE, 6GCW, 6GCX, 4D5K, 4D55, 2J0M, 2AL6, 2J0L, 2J0K, 6GCR, 2J0J, 2AEH, 4D58, 1KTM, 4D4V, 4BRX, 4C7T, 4D5H, 2JKO, 1QVX, 2JKM, 4D4Y, 6CB0, 2L6F, 2JKK

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00944	10	phospho-p-Y194,Y397-PTK2 [cytosol] (R-GGA-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-GGA-8874613) phospho-pY-PTK2 [cytosol] (R-GGA-9632393) phospho-p-5Y-PTK2 [cytosol] (R-GGA-5218711) phospho-p-5Y,S732-PTK2 [cytosol] (R-GGA-5229006) phospho-p-6Y,S732-PTK2 [cytosol] (R-GGA-5218694) phospho-p-Y397-PTK2 [cytosol] (R-GGA-354068) PTK2 [cytosol] (R-GGA-201621) PTK2(1-772) [cytosol] (R-GGA-202827) PTK2(773-1052) [cytosol] (R-GGA-202829)	0.656	3
UniProt:P61157 ACTR3	1	ARP3 [cytosol] (R-BTA-419940)	0.612	5
UniProt:P49024 PAXI			0.609	2
UniProt:P08581 MET	7	p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.602	5
UniProt:P00523 SRC	9	phospho-p-Y416-SRC [cytosol] (R-GGA-8964276) SRC [cytosol] (R-GGA-9628701) MyrG-SRC [plasma membrane] (R-GGA-8876922) Src [cytosol] (R-GGA-3928468) phospho-p-Y419-SRC [cytosol] (R-GGA-377592) SRC-1 [plasma membrane] (R-GGA-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-GGA-377598) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-GGA-1810408) SRC-2 [cytosol] (R-GGA-191648)	0.589	3