Reactome | phospho-p-Y31,Y118-PXN [cytosol]

phospho-p-Y31,Y118-PXN [cytosol]

Stable Identifier

R-GGA-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

A0A1D5PGG4

Locations in the PathwayBrowser

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Signal Transduction (Gallus gallus)

- Signaling by Non-Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by PTK6 (Gallus gallus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Gallus gallus)
      - Activation of RAC1 by the PXN:CRK complex (Gallus gallus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
      - Phosphorylated PXN recruits the CRK complex (Gallus gallus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - CRK binds BCAR1 and or PXN (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
      - DOCK180:ELMO binds CRK (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PGG4

Reference Genes

ENSEMBL:ENSGALG00000007247

Participates

as a component of

as an input of

Phosphorylated PXN recruits the CRK complex (Gallus gallus)

Other forms of this molecule

phospho-p-Y-PXN [plasma membrane]

PXN [plasma membrane]

PXN [cytosol]

Inferred From

p-Y31,Y118-PXN [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.