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GAB2 [cytosol]
Stable Identifier
R-GGA-508239
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A3Q2UDN3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
RET signaling (Gallus gallus)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Gallus gallus)
GAB1,GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Gallus gallus)
GAB1,GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
GAB1,GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Gallus gallus)
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Indirect recruitment of GAB2 to p-KIT (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
Phosphorylation of GAB2 by SFKs (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GAB2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q2UDN3
Reference Genes
ENSEMBL:ENSGALG00000054619
Participates
as a member of
GAB1,GAB2 [cytosol] (Gallus gallus)
as a component of
GRB2:GAB2 [cytosol] (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
as an input of
Indirect recruitment of GAB2 to p-KIT (Gallus gallus)
Other forms of this molecule
phospho-p-Y643-GAB2 [cytosol]
phospho-p-5Y-GAB2 [cytosol]
phospho-p-Y452,Y476,Y584-GAB2 [cytosol]
phospho-p-Y-GAB2 [cytosol]
Inferred From
GAB2 [cytosol]
(Homo sapiens)
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