Reactome | Dimerization of activated ERK2

Dimerization of activated ERK2

Stable Identifier

R-GGA-451535

Type

Reaction [binding]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR15 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)
  - TLR2 subfamily cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)
  - TLR21 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)
  - TLR3 cascade (Gallus gallus)
    - TRAF6 mediated induction of proinflammatory cytokines (Gallus gallus)
      - MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)
  - TLR4 cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)
  - TLR5 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)
  - TLR7 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        ERK activation (Gallus gallus)
        
        Dimerization of activated ERK2 (Gallus gallus)

General

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MEK-ERK pathways are considered to be highly conserved. Their involvement in up-regulation of the inflammatory response has been demonstrated in mammals and chicken (Johnson GL and Lapadat R 2002; Kogut M et al 2008).

In this model we assume that chicken MEK-ERK mediators behave like their human counterparts.

Literature References

PubMed ID	Title	Journal	Year
18669607	Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways Kogut, MH, Genovese, KJ, He, H, Kaiser, P	Innate Immun	2008
17045653	Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1 Kogut, MH, Genovese, KJ, He, H	Mol Immunol	2007