Although functional assays showed that chicken cells respond to known mammalian TLR7 and TLR9 ligands in vitro and in ovo [Philbin et al 2005, Jenkins KA et al 2009], bioinformatics analysis of the chicken genome have identified a disrupted ortholog of TLR8 and no direct ortholog of TLR9. Only TLR7 gene was found intact[Philbin et al 2005, Temperley ND et al 2008].The chicken TLR7 (chTLR7) amino acid sequence shows 62% identity to its human counterpart. chTLR7 mRNA was detected in immune-related tissues - spleen, caecal tonsil [Iqbal et al 2005, Phiblin et al 2005]. Chicken leukocytes, heterophils, monocytes and the chicken macrophage cell line HD11 have been also shown to express chTLR7 [Philbin et al 2005].
Temperley, ND, Berlin, S, Paton, IR, Griffin, DK, Burt, DW
Philbin, VJ, Iqbal, M, Boyd, Y, Goodchild, MJ, Beal, RK, Bumstead, N, Young, J, Smith, AL
Kogut, MH, Iqbal, M, He, H, Philbin, V, Kaiser, P, Smith, A
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