Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
IRF-3 [cytosol]
Stable Identifier
R-GGA-450281
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
IRF7, Q90ZD4
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Gallus gallus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)
IRF-3 [cytosol] (Gallus gallus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Gallus gallus)
IRF-3 [cytosol] (Gallus gallus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Gallus gallus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Gallus gallus)
IRF-3 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q90ZD4
Gene Names
IRF-3
Reference Genes
BioGPS Gene:396330 IRF-3
ENSEMBL:ENSGALG00000014297
ENSEMBL:ENSGALG00010023005.1 IRF-3
KEGG Gene (Gallus gallus):396330 IRF-3
Monarch:396330 IRF-3
NCBI Gene:396330 IRF-3
Reference Transcript
RefSeq:NM_205372.1 IRF-3
Other Identifiers
396330
GO:0000976
GO:0000978
GO:0000981
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0006351
GO:0006355
GO:0006357
GO:0043226
GO:0045893
GO:0140110
GT_A_87_P053671
Gga.1087.1.S1_at
Participates
as an input of
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)
as a component of
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Gallus gallus)
Other forms of this molecule
phospho-IRF-3 [nucleoplasm]
phospho-IRF-3 [cytosol]
Inferred From
IRF3,IRF7 [cytosol]
(Homo sapiens)
IRF7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_990703.1
Ensembl
ENSGALT00010056028
,
ENSGALP00010033902
,
ENSGALG00010023005
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text