Cis-heterodimerization of NgCAM and DM-GRASP/ALCAM

Stable Identifier
R-GGA-443781
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cis-heterodimerization of NgCAM and DM-GRASP/ALCAM
DM GRASP/ALCAM/BEN is one of the heterodimerizing partners for L1/NgCAM. Interation between L1/NgCAM and DM GRASP in the growth cone membrane is involved in L1 stimulated neurite outgrowth. Trans binding of L1 on retinal growth cones to ALCAM on the superior colliculus potentiates adhesion, leading to correct synaptic targeting.
Literature References
PubMed ID Title Journal Year
8636239 Heterophilic interactions of DM-GRASP: GRASP-NgCAM interactions involved in neurite extension

DeBernardo, AP, Chang, S

J Cell Biol 1996
Participants
Input
Output
Orthologous Events
Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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