Reactome | DLG3 [plasma membrane]

DLG3 [plasma membrane]

Stable Identifier

R-GGA-443609

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

DLG3, A0A3Q2U4B8

Locations in the PathwayBrowser

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Neuronal System (Gallus gallus)

- Protein-protein interactions at synapses (Gallus gallus)
  - Synaptic adhesion-like molecules (Gallus gallus)
    - SALMs 1-3 bind to PSD-95 family members (Gallus gallus)
      - PSD-95 family [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
      - SALMs 1-3:PSD-95 family [plasma membrane] (Gallus gallus)
        
        PSD-95 family [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
- Transmission across Chemical Synapses (Gallus gallus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
    - Activation of NMDA receptors and postsynaptic events (Gallus gallus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)
        
        Ca2+ influx into the post-synaptic cell (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
    - Activation of kainate receptors upon glutamate binding (Gallus gallus)
      - Ionotropic activity of kainate receptors (Gallus gallus)
        
        Activation of Ca-permeable Kainate Receptor (Gallus gallus)
        
        Activation of Ca-permeable Kainate receptors (Gallus gallus)
        
        Kainate receptor-glutamate complex [plasma membrane] (Gallus gallus)
        
        Kainate Receptors [plasma membrane] (Gallus gallus)
        
        GRIK 2 homomer [plasma membrane] (Gallus gallus)
        
        GRIK2 interacting proteins [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
        
        GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Gallus gallus)
        
        GRIK4 interacting proteins [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
        
        kainate receptor binds glutamate (Gallus gallus)
        
        Kainate Receptors [plasma membrane] (Gallus gallus)
        
        GRIK 2 homomer [plasma membrane] (Gallus gallus)
        
        GRIK2 interacting proteins [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
        
        GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Gallus gallus)
        
        GRIK4 interacting proteins [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
        
        Kainate receptor-glutamate complex [plasma membrane] (Gallus gallus)
        
        Kainate Receptors [plasma membrane] (Gallus gallus)
        
        GRIK 2 homomer [plasma membrane] (Gallus gallus)
        
        GRIK2 interacting proteins [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)
        
        GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Gallus gallus)
        
        GRIK4 interacting proteins [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        DLG3 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2U4B8

Gene Names

DLG3

Reference Genes

BioGPS Gene:428706 DLG3

ENSEMBL:ENSGALG00000041900

ENSEMBL:ENSGALG00010018559.1 DLG3

KEGG Gene (Gallus gallus):428706 DLG3

Monarch:428706 DLG3

NCBI Gene:428706 DLG3

Reference Transcript

RefSeq:XM_015278412.1 DLG3

Other Identifiers

428706

GO:0001736

GO:0005515

GO:0005737

GO:0005886

GO:0005911

GO:0005923

GO:0007155

GO:0007163

GO:0007268

GO:0016020

GO:0016323

GO:0019900

GO:0019902

GO:0023052

GO:0031594

GO:0031625

GO:0032281

GO:0043005

GO:0043113

GO:0043226

GO:0045197

GO:0048856

GO:0097120

GO:0098609

GO:0098839

GO:0098978

GO:0099072

GT_A_87_P017989

GT_Sp_Chicken_BG642056_459

GT_Sp_Chicken_CN225699_5135

Gga.14060.1.S1_s_at

Gga.5402.1.S1_at

GgaAffx.26616.1.S1_s_at

Participates

as a member of

as a component of

Inferred From

DLG3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_015133898.1

OpenTargets

ENSG00000082458

Ensembl

ENSGALP00010026819, ENSGALT00010044904, ENSGALG00010018559

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