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The tricarboxylic acid cycle
Stable Identifier
R-GGA-372987
Type
Pathway
Species
Gallus gallus
Compartment
mitochondrial matrix
ReviewStatus
5/5
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Metabolism (Gallus gallus)
The tricarboxylic acid cycle (Gallus gallus)
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The reactions of the tricarboxylic acid (TCA cycle) mediate the complete oxidation of two carbon atoms from acetyl CoA, derived from catabolism of glucose and long chain fatty acids, to CO2, and the generation of NADH + H+ and FADH2. Carbon skeletons derived from catabolism of amino acids enter the TCA cycle as oxaloacetate, 2-oxoglutarate, and succinyl CoA. The TCA cycle thus plays a central role in the generation of energy by catabolism of energy-rich molecules from the diet, but also plays a critical role in the interconversions of metabolic intermediates needed to maintain pools of amino acids and other metabolites at physiological levels.
Participants
Events
acetyl-CoA + H2O + oxaloacetate => citrate + CoA
(Gallus gallus)
citrate <=> isocitrate
(Gallus gallus)
isocitrate <=> citrate
(Gallus gallus)
isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+
(Gallus gallus)
2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+
(Gallus gallus)
succinylCoA + GDP + Pi <=> succinate + CoASH + GTP
(Gallus gallus)
succinate + CoASH + GTP <=> succinylCoA + GDP + Pi
(Gallus gallus)
succinylCoA + ADP + Pi <=> succinate + CoASH + ATP
(Gallus gallus)
succinate + CoASH + ATP <=> succinylCoA + ADP + Pi
(Gallus gallus)
succinate + FAD <=> fumarate + FADH2
(Gallus gallus)
fumarate + FADH2 <=> succinate + FAD
(Gallus gallus)
fumarate + H2O <=> malate
(Gallus gallus)
malate <=> fumarate + H2O
(Gallus gallus)
malate + NAD+ <=> oxaloacetate + NADH + H+
(Gallus gallus)
Participates
as an event of
Metabolism (Gallus gallus)
Event Information
Go Biological Process
tricarboxylic acid cycle (0006099)
Authored
D'Eustachio, P (2008-09-10)
Created
D'Eustachio, P (2008-07-11)
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