Reactome | 2-phosphoglycerate <=> phosphoenolpyruvate + H2O

2-phosphoglycerate <=> phosphoenolpyruvate + H2O

Stable Identifier

R-GGA-353044

Type

Reaction [transition]

Species

Gallus gallus

Compartment

cytosol

Synonyms

Dehydration of 2-phosphoglycerate to form phosphoenolpyruvate

ReviewStatus

5/5

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2-phosphoglycerate <=> phosphoenolpyruvate + H2O

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Cytosolic enolase catalyzes the reversible magnesium-dependent dehydration of 2-phosphoglycerate to form phosphoenolpyruvate. The active form of the enzyme is a dimer. Three enolase isoforms have been isolated and biochemically characterized, 1 (alpha), 2 (gamma), and 3 (beta), as have 1:1, 1:2, 2:2, and 3:3 enolase dimers (Russell et al. 1986; Tanaka et al. 1985, 1995, 1998).

Literature References

PubMed ID	Title	Journal	Year
9434147	cDNA cloning and characterization of neuron-specific enolase from chicken Tanaka, M, Taniguchi, T, Ohkubo, T, Nakashima, K	Biochim Biophys Acta	1998
7629021	Chicken alpha-enolase but not beta-enolase has a Src-dependent tyrosine-phosphorylation site: cDNA cloning and nucleotide sequence analysis Tanaka, M, Maeda, K, Nakashima, K	J Biochem	1995
3539098	The complete amino acid sequence of chicken skeletal-muscle enolase Russell, GA, Dunbar, B, Fothergill-Gilmore, LA	Biochem J	1986
4093440	Purification, characterization, and distribution of enolase isozymes in chicken Tanaka, M, Sugisaki, K, Nakashima, K	J Biochem	1985