iC3b proteolysis

Stable Identifier
R-GGA-2530565
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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iC3b proteolysis
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In mammals, inactivated C3b (iC3b) undergoes proteolytic cleavage mediated by factor I. This cleavage occurs only if CR1serves as a cofactor. C3d is a fragment of a cleaved C3b which is generated in the course of complement activation. The gene fragment encoding C3d (chC3d) from Roman chicken was cloned and characterized. However the chicken events of C3b cleavage have not been verified experimentally in chicken and are therefore inferred from properties of the orthologous human proteins.
Literature References
PubMed ID Title Journal Year
18798021 Cloning of a gene fragment encoding chicken complement component C3d with expression and immunogenicity of Newcastle disease virus F gene-C3d fusion protein

Liu, D, Niu, ZX

Avian Pathol. 2008
21788512 Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

Alcorlo, M, Martínez-Barricarte, R, Fernández, FJ, Rodríguez-Gallego, C, Round, A, Vega, MC, Harris, CL, de Córdoba, SR, Llorca, O

Proc. Natl. Acad. Sci. U.S.A. 2011
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of CFI [extracellular region]

Physical Entity
CFI [extracellular region] (Gallus gallus)
Activity
serine-type endopeptidase activity (GO:0004252)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-10-17)
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