Reactome | Complement factor B binds to surface-bound C3b fragment

Complement factor B binds to surface-bound C3b fragment

Stable Identifier

R-GGA-2132061

Type

Reaction [binding]

Species

Gallus gallus

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Complement factor B binds to surface-bound C3b fragment

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Surface-bound C3b interacts with factor B which in turn is cleaved into two fragments, Ba and Bb. Ba is released, whereas Bb remains bound to C3b, forming a C3 convertase.

Literature References

PubMed ID	Title	Journal	Year
279011	Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins Schreiber, RD, Pangburn, MK, Lesavre, PH, Muller-Eberhard, HJ	Proc Natl Acad Sci U S A	1978
2587932	Purification of chicken C3 and a structural and functional characterization Laursen, I, Koch, C	Scand J Immunol	1989
7532662	Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family Mavroidis, M, Sunyer, JO, Lambris, JD	J Immunol	1995

Participants

Input

Output

C3b:factor B [plasma membrane] (Gallus gallus)

Participates

as an event of

Formation of membrane-bound convertase C3 (Gallus gallus)

This event is regulated

Positively by

Regulator

Mg2+ [extracellular region]

Inferred From

Factor B binds to surface-associated C3b (Homo sapiens)

Authored

Shamovsky, V (2012-12-20)

Reviewed

D'Eustachio, P (2012-11-07)

Jupe, S (2013-01-31)

Created

Shamovsky, V (2012-02-21)

Cite Us!