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SQSTM1 [cytosol]
Stable Identifier
R-GGA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
SQSTM1, A0A1D5PLN4
Locations in the PathwayBrowser
Expand all
Autophagy (Gallus gallus)
Macroautophagy (Gallus gallus)
Selective autophagy (Gallus gallus)
Mitophagy (Gallus gallus)
PINK1-PRKN Mediated Mitophagy (Gallus gallus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Gallus gallus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Gallus gallus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Gallus gallus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
p62 links damaged mitochondria to LC3 (Gallus gallus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Gallus gallus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
Pexophagy (Gallus gallus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
KEAP1-NFE2L2 pathway (Gallus gallus)
SQSTM1 oligomerizes (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 oligomer [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
TRIM21 ubiquitinates SQSTM1 (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 signaling (Gallus gallus)
p62:MEKK3 binds to TRAF6 (Gallus gallus)
MAP3K3:SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Gallus gallus)
MAP3K3:SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
p75 NTR receptor-mediated signalling (Gallus gallus)
Cell death signalling via NRAGE, NRIF and NADE (Gallus gallus)
NRIF signals cell death from the nucleus (Gallus gallus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
p75NTR signals via NF-kB (Gallus gallus)
NF-kB is activated and signals survival (Gallus gallus)
IKKbeta is activated (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
p75NTR recruits signalling complexes (Gallus gallus)
IKK-beta is recruited (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
TRAF6 is auto-ubiquitinated (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
p62 is recruited and forms a complex with TRAF6 (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
p62 recruits an atypical PKC (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
SQSTM1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5PLN4
Gene Names
SQSTM1
Reference Genes
BioGPS Gene:770805 SQSTM1
ENSEMBL:ENSGALG00000035804
ENSEMBL:ENSGALG00010016907.1 SQSTM1
KEGG Gene (Gallus gallus):770805 SQSTM1
Monarch:770805 SQSTM1
NCBI Gene:770805 SQSTM1
Reference Transcript
RefSeq:XM_001233248.4 SQSTM1
Other Identifiers
770805
GO:0000122
GO:0000407
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0005080
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005776
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0007005
GO:0007032
GO:0008270
GO:0010508
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030163
GO:0030674
GO:0031397
GO:0031625
GO:0034614
GO:0035255
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0044753
GO:0044754
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0061912
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0098780
GO:0140036
GO:1900273
GO:1903078
GO:1905719
GT_A_87_P022703
GT_A_87_P073096
GT_A_87_P202173
GT_A_87_P208473
Gga.5187.1.S1_at
Gga.5187.1.S1_s_at
GgaAffx.26656.1.S1_at
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Gallus gallus)
SQSTM1 oligomerizes (Gallus gallus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)
p62 is recruited and forms a complex with TRAF6 (Gallus gallus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)
p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)
as a component of
SQSTM1 oligomer [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Gallus gallus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Gallus gallus)
MAP3K3:SQSTM1 [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Gallus gallus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Gallus gallus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Gallus gallus)
Other forms of this molecule
SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_001233249.2
OpenTargets
ENSG00000161011
Ensembl
ENSGALG00010016907
,
ENSGALP00010023771
,
ENSGALT00010040807
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