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phospho-MyrG-p-Y419-SRC [plasma membrane]
Stable Identifier
R-GGA-1810408
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
P00523
Locations in the PathwayBrowser for interactor UniProt:P61980
Expand all
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX3 (Gallus gallus)
Regulation of RUNX3 expression and activity (Gallus gallus)
RUNX3 binds SRC (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
RUNX3 translocates to the nucleus (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SRC phosphorylates RUNX3 (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB4 (Gallus gallus)
Downregulation of ERBB4 signaling (Gallus gallus)
ERBB4s80 binds to SRC (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by MET (Gallus gallus)
MET promotes cell motility (Gallus gallus)
MET activates PTK2 signaling (Gallus gallus)
p-Y397-PTK2 binds SRC (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:P00523 SRC
Gene Names
SRC
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:396442 SRC
KEGG Gene (Gallus gallus):396442 SRC
Monarch:396442 SRC
NCBI Gene:396442 SRC
Reference Transcript
RefSeq:XM_015296348.1 SRC
RefSeq:NM_205457.2 SRC
Participates
as a component of
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
as an input of
ERBB4s80 binds to SRC (Gallus gallus)
RUNX3 binds SRC (Gallus gallus)
p-Y397-PTK2 binds SRC (Gallus gallus)
as an output of
SRC phosphorylates RUNX3 (Gallus gallus)
as a member of
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Gallus gallus)
as a candidate of
RAF activating kinases [plasma membrane] (Gallus gallus)
This entity regulates
Negatively
RUNX3 translocates to the nucleus
(Gallus gallus)
Other forms of this molecule
SRC [cytosol]
phospho-p-Y419-SRC [cytosol]
MyrG-SRC [plasma membrane]
Src [cytosol]
SRC-1 [plasma membrane]
phospho-p-Y419-SRC [cytosol]
phospho-MyrG,p-Y530-SRC [plasma membrane]
SRC-2 [cytosol]
Inferred From
MyrG-p-Y419-SRC [plasma membrane]
(Homo sapiens)
Modified Residues
Name
N-myristoylglycine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Name
O4'-phospho-L-tyrosine at 419 (in Homo sapiens)
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_015151834.1
,
NP_990788.2
ZINC - Investigational
SRC_CHICK
ZINC - World Drugs
SRC_CHICK
OpenTargets
ENSG00000197122
ZINC - FDA approved
SRC_CHICK
ZINC - Substances
SRC_CHICK
ZINC target
P00523
PRO
P00523
ZINC - Predictions - Purchasable
SRC_CHICK
PDB
7AH3
,
7PVZ
,
2HWP
,
1NLO
,
1PRM
,
3EN5
,
7A3C
,
7A3A
,
4MCV
,
7PVX
,
4HVU
,
4OMM
,
7PVW
,
5D10
,
5XP5
,
3G5D
,
7A32
,
5SWH
,
3EN6
,
5K9I
,
4LE9
,
3EN7
,
5D11
,
7A3E
,
6L8L
,
3U4W
,
2OIQ
,
7A35
,
3UQG
,
1RLQ
,
4RTV
,
3G6G
,
4RTX
,
5OB2
,
5OAV
,
7A36
,
1NLP
,
7A3B
,
3QLF
,
3F3W
,
7WF5
,
2QQ7
,
3TZ9
,
7A31
,
4DGG
,
3DQW
,
6XVO
,
4OMP
,
1P13
,
3SVV
,
3DQX
,
7NES
,
5OB0
,
6HVF
,
3D7U
,
5J5S
,
5BMM
,
6XX5
,
6XX3
,
6WIW
,
2PTK
,
7A39
,
2HWO
,
4QT7
,
4RTZ
,
7A3D
,
3TZ7
,
3FJ5
,
7PVY
,
7D57
,
4U5J
,
4O2P
,
1PRL
,
7PW0
,
2QLQ
,
4OML
,
2QI8
,
4RTU
,
3QLG
,
3UQF
,
3TZ8
,
7A30
,
4HVV
,
5D12
,
5EC7
,
3U51
,
4FIC
,
4HVW
,
4OMN
,
4YBJ
,
7A34
,
4OMQ
,
5SYS
,
4LGG
,
6HVE
,
1RLP
,
3F3T
,
3F6X
,
4LGH
,
7A37
,
4RTW
,
3F3U
,
6XVN
,
3EN4
,
5XP7
,
4RTY
,
1F1W
,
6XVM
,
5I11
,
4JZ4
,
3F3V
,
7A33
,
3LOK
,
1SRM
,
4OMO
,
3GEQ
,
7NET
,
4AGW
,
5OB1
,
3D7T
,
7NER
,
3EL7
,
7D5O
,
1SRL
,
6XX4
,
3OF0
,
4YBK
,
5TEH
,
7A38
,
3EL8
,
5ECA
,
6XX2
,
1F2F
,
4JZ3
,
3G6H
,
3OEZ
,
5T0P
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41240 CSK
2
CSK [plasma membrane]
(R-HSA-180499)
CSK [cytosol]
(R-HSA-203776)
0.719
7
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.59
4
UniProt:Q00944
11
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2 [cytosol]
(R-GGA-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
0.589
3
UniProt:O88703
1
HCN2 [plasma membrane]
(R-MMU-977502)
0.581
5
UniProt:Q9QWY8-1 ASAP1
0.581
3
UniProt:Q90738 AFAP1
0.564
3
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.564
2
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.556
3
UniProt:Q9QWY8-2 ASAP1
0.544
2
UniProt:P61980
2
Hnrnpk [nucleoplasm]
(R-RNO-4570532)
Hnrnpk [nucleoplasm]
(R-RNO-71945)
0.544
2
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.525
2
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