Reactome | TANK binds polyubiquitinated TRAF3/6

TANK binds polyubiquitinated TRAF3/6

Stable Identifier

R-GGA-1227867

Type

Reaction [binding]

Species

Gallus gallus

Related Species

Infectious bronchitis virus

Compartment

mitochondrial outer membrane, cytosol

ReviewStatus

5/5

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TANK (TRAF family member-associated NF-kB activator) is a TRAF-binding protein [Rothe M et al 1996; Pomeranz JL and Baltimore D 1999; Li C et al 2002; Guo B and Cheng G 2007; Konno H 2009] that has been implicated in RLR, TNFR and IL-1R/TLR signaling pathways in mammals. TANK was also shown to interact with TBK1, IKK epsilon, IPS-1, TRIF and IRF3 [Pomeranz JL and Baltimore D 1999,Guo B and Cheng G 2007]. Upon viral stimulation TANK is believed to induce type I IFN production by linking kinases TBK1/IKK epsilon with upstream mediators, while its role in NF-kB signaling remains elusive. TANK was reported to act as either positive[GuoB and Cheng G 2007, Konno H et al 2009, Pomerantz JL and Baltimore D 1999] or negative regulator of TRAF-mediated NF-kB induction [Kawagoe T et al 2009].

Predicted chicken TANK protein shows 51% amino acid sequence identity to its human counterpart.

Literature References

PubMed ID	Title	Journal	Year
17332413	Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity Garcia-Sastre, A, Chua, MA, Ng, SL, McWhirter, SM, Tenoever, BR, Maniatis, T	Science	2007
17327220	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK Guo, B, Cheng, G	J Biol Chem	2007