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CBL [cytosol]
Stable Identifier
R-GGA-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1NXW5
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Regulation of signaling by CBL (Gallus gallus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)
CBL [cytosol] (Gallus gallus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Interleukin-6 family signaling (Gallus gallus)
Interleukin-6 signaling (Gallus gallus)
PTPN11 binds CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
EGFR downregulation (Gallus gallus)
Binding of CBL to EGFR (Gallus gallus)
CBL [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL binds to GRB2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL ubiquitinates Sprouty (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL-mediated ubiquitination of CIN85 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Localization of CBL:GRB2 to the membrane (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylation of CBL (EGFR:CBL) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Sprouty lures CBL away from EGFR (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:SPRY1/2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Negative regulation of FGFR1 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR2 (Gallus gallus)
Negative regulation of FGFR2 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR3 (Gallus gallus)
Negative regulation of FGFR3 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by FGFR4 (Gallus gallus)
Negative regulation of FGFR4 signaling (Gallus gallus)
Spry regulation of FGF signaling (Gallus gallus)
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by MET (Gallus gallus)
Negative regulation of MET activity (Gallus gallus)
CBL binds MET (Gallus gallus)
CBL:GRB2,CBL [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
MET phosphorylates CBL (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Regulation of KIT signaling (Gallus gallus)
Recruitment of CBL to KIT (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
Signaling by TGFB family members (Gallus gallus)
Signaling by TGF-beta Receptor Complex (Gallus gallus)
TGF-beta receptor signaling activates SMADs (Gallus gallus)
CBL binds TGFBR2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
TGFBR2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
CBL neddylates TGFBR2 (Gallus gallus)
CBL [cytosol] (Gallus gallus)
TGFBR2:CBL [plasma membrane] (Gallus gallus)
CBL [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NXW5
Reference Genes
ENSEMBL:ENSGALG00000029077
Participates
as an input of
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)
PTPN11 binds CBL (Gallus gallus)
Recruitment of CBL to KIT (Gallus gallus)
CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)
Sprouty lures CBL away from EGFR (Gallus gallus)
CBL binds to GRB2 (Gallus gallus)
Binding of CBL to EGFR (Gallus gallus)
CBL binds TGFBR2 (Gallus gallus)
as a component of
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Gallus gallus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Gallus gallus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Gallus gallus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Gallus gallus)
CBL:SPRY1/2 [cytosol] (Gallus gallus)
CBL:GRB2 [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
TGFBR2:CBL [plasma membrane] (Gallus gallus)
as a candidate of
CBL:GRB2,CBL [cytosol] (Gallus gallus)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)
CBL neddylates TGFBR2 (Gallus gallus)
Other forms of this molecule
phospho-p-Y-CBL [cytosol]
phospho-p-Y371-CBL [cytosol]
phospho-p-Y371-CBL [plasma membrane]
phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
phospho-p-Y700,Y731,Y774-CBL [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
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