Reactome | kctd6 [cytosol]

kctd6 [cytosol]

Stable Identifier

R-DRE-8863321

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

KCTD6, Q6DG99

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kctd6 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6DG99

Gene Names

kctd6

Reference Genes

BioGPS Gene:436601 kctd6

CTD Gene:436601 kctd6

ENSEMBL:ENSDARG00000023703

KEGG Gene (Danio rerio):436601 kctd6

Monarch:436601 kctd6

NCBI Gene:436601 kctd6

Reference Transcript

RefSeq:NM_001002329.1 kctd6

Other Identifiers

13133000

436601

A_15_P108227

A_15_P108857

CUST_8816_PI428451958

DRER03985

ENSDART00000031872

ENSDART00000031872_1

ENSDART00000031872_2

GO:0005515

GO:0051260

GO:0065003

GT_Spec_NM_001002329.1_199765

MADDr01001534

NM_001002329

Participates

as a member of

BTB proteins [cytosol] (Danio rerio)

Inferred From

KCTD6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001002329.1

ZFIN

ZDB-GENE-040718-14

Ensembl

ENSDART00000031872, ENSDARP00000034172, ENSDARG00000023703

PRO

Q6DG99

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