Reactome | bb02h10 [cytosol]

bb02h10 [cytosol]

Stable Identifier

R-DRE-72486

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL7, Q6Q417

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        bb02h10 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6Q417

Gene Names

bb02h10

Reference Genes

BioGPS Gene:336710 bb02h10

ENSEMBL:ENSDARG00000007320

ENSEMBL:ENSDARG00000007320.10 bb02h10

KEGG Gene (Danio rerio):336710 bb02h10

Monarch:336710 bb02h10

NCBI Gene:336710 bb02h10

Reference Transcript

RefSeq:NM_213644.2 bb02h10

Other Identifiers

13089377

336710

A_15_P118772

A_15_P121422

A_15_P562217

A_15_P578607

A_15_P727698

A_15_P739246

BC107515

DRER02385

DRER32557

Dr.25458.1.S1_at

ENSDART00000019149

ENSDART00000019149_1

ENSDART00000019149_2

GO:0000463

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0022625

GO:0042254

GO:0043226

GO:0051726

LOLS11740

MADDr01007693

NM_213644

ZV700S00004459

Participates

as a component of

Inferred From

RPL7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_998809.1

ZFIN

ZDB-GENE-030131-8654

Ensembl

ENSDARG00000007320, ENSDART00000019149, ENSDARP00000018980

PDB

7OYB, 7OYA

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