Reactome | zgc:63840 [nucleoplasm]

zgc:63840 [nucleoplasm]

Stable Identifier

R-DRE-53489

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

DDB1, Q6PGT6

Locations in the PathwayBrowser

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DNA Repair (Danio rerio)

- Nucleotide Excision Repair (Danio rerio)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
    - DNA Damage Recognition in GG-NER (Danio rerio)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Danio rerio)
        
        UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Danio rerio)
        
        UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Danio rerio)
        
        UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
    - Dual Incision in GG-NER (Danio rerio)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
    - Formation of Incision Complex in GG-NER (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - CHD1L is recruited to GG-NER site (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - TFIIH binds GG-NER site to form a verification complex (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        PAR-UV-DDB [nucleoplasm] (Danio rerio)
        
        DDB1:PAR-DDB2 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
    - Dual incision in TC-NER (Danio rerio)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
    - Formation of TC-NER Pre-Incision Complex (Danio rerio)
      - UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        zgc:63840 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PGT6

Gene Names

zgc:63840

Reference Genes

BioGPS Gene:393599 zgc:63840

ENSEMBL:ENSDARG00000074431

KEGG Gene (Danio rerio):393599 zgc:63840

Monarch:393599 zgc:63840

NCBI Gene:393599 zgc:63840

Reference Transcript

RefSeq:NM_200626.1 zgc:63840

Participates

as a component of

Inferred From

DDB1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_956920.1

ZFIN

ZDB-GENE-040426-1272

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