Reactome | gng12b [plasma membrane]

gng12b [plasma membrane]

Stable Identifier

R-DRE-164367

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

GNG12, A0A0R4IHM6

Locations in the PathwayBrowser

Expand all

Hemostasis (Danio rerio)

- Platelet activation, signaling and aggregation (Danio rerio)
  - Signal amplification (Danio rerio)
    - ADP signalling through P2Y purinoceptor 12 (Danio rerio)
      - Gi activation by P2Y purinoceptor 12 (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
    - Thromboxane signalling through TP receptor (Danio rerio)
      - G13 activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
      - Gq activation by TP receptor (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
  - Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
    - Thrombin-activated PARs activate Gq (Danio rerio)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)

Metabolism (Danio rerio)

- Integration of energy metabolism (Danio rerio)
  - Regulation of insulin secretion (Danio rerio)
    - Adrenaline,noradrenaline inhibits insulin secretion (Danio rerio)
      - Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)
        
        G-alpha(i,o):GDP:G beta:G gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
      - G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)
        
        Adenylate cyclase type V or VI: G-protein beta gamma Complex [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
      - Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)
        
        G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Danio rerio)
      - GLP1R binds GLP1R agonists (Danio rerio)
        
        GLP1R:GLP1R agonists [plasma membrane] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
      - Opsins act as GEFs for G alpha-t (Danio rerio)
        
        G-alpha(t):GDP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GDP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        G-alpha(t):GTP:G-beta-gamma:Opsins [plasma membrane] (Danio rerio)
        
        G-alpha(t)-GTP:G-beta-gamma [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Danio rerio)
        
        G-protein beta-gamma complex [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)

Transport of small molecules (Danio rerio)

- Aquaporin-mediated transport (Danio rerio)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Danio rerio)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Danio rerio)
        
        G-beta:G-gamma (candidates) [plasma membrane] (Danio rerio)
        
        G-protein gamma subunit [plasma membrane] (Danio rerio)
        
        gng12b [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A0R4IHM6

Gene Names

gng12b

Reference Genes

BioGPS Gene:100331581 gng12b

ENSEMBL:ENSDARG00000098123

ENSEMBL:ENSDARG00000098123.2 gng12b

ENSEMBL:ENSDARG00000114225.1 gng12b

KEGG Gene (Danio rerio):100331581 gng12b

Monarch:100331581 gng12b

NCBI Gene:100331581 gng12b

Reference Transcript

Other Identifiers

100331581

13220041

13302010

A_15_P549347

CUST_16182_PI428451953

DRER49004

DRER49763

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0031681

Participates

as a candidate of

Inferred From

GNG12 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_002662464.1, XP_005168803.1, XP_017212106.1, XP_021332780.1, XP_021332779.1

ZFIN

ZDB-GENE-091020-2

Ensembl

ENSDART00000185344, ENSDARG00000114225, ENSDART00000168511, ENSDARP00000133096, ENSDARP00000156473, ENSDART00000186164, ENSDARG00000098123, ENSDARP00000150753

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