Reactome | pabpc1a [cytosol]

pabpc1a [cytosol]

Stable Identifier

R-DRE-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

PABPC1, F1QB54

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
      - mRNA Cleaved by SMG6 [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
- Regulation of mRNA stability by proteins that bind AU-rich elements (Danio rerio)
  - AUF1 (hnRNP D0) binds and destabilizes mRNA (Danio rerio)
    - AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)
      - AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Translation (Danio rerio)
  - Eukaryotic Translation Initiation (Danio rerio)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Danio rerio)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Danio rerio)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Danio rerio)
        
        pabpc1a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QB54

Gene Names

pabpc1a

Reference Genes

BioGPS Gene:606498 pabpc1a

CTD Gene:606498 pabpc1a

ENSEMBL:ENSDARG00000017219

KEGG Gene (Danio rerio):606498 pabpc1a

Monarch:606498 pabpc1a

NCBI Gene:606498 pabpc1a

Reference Transcript

Other Identifiers

13035468

606498

A_15_P133836

A_15_P207606

A_15_P434175

A_15_P544072

A_15_P656726

A_15_P731106

A_15_P736096

CUST_1711_PI428451958

CUST_25604_PI428451953

CUST_25605_PI428451953

DRER03193

DRER46515

DRER47212

DRER47346

DRER47523

DRER47669

Dr.12233.1.S1_at

Dr.12233.1.S2_a_at

Dr.12233.2.S1_x_at

ENSDART00000024729

ENSDART00000024729_1

ENSDART00000024729_2

GO:0003676

GO:0003723

GO:0003730

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006397

GO:0006412

GO:0006417

GO:0007507

GO:0008143

GO:0008266

GO:0010494

GO:0016071

GO:0043226

GO:0048856

GO:1990904

GT_Spec_XM_005169771.1_44001

GT_Xhyb_NM_001031676.1_322725

MADDr01001111

NM_001031676

ZV700S00000607

ZV700S00000608

Participates

as a component of

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005169828.1, NP_001026846.1

ZFIN

ZDB-GENE-030131-3238

Ensembl

ENSDART00000148392, ENSDARP00000124828, ENSDARG00000017219, ENSDART00000024729, ENSDARP00000021064

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