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About
What is Reactome ?
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Ub [cytosol]
Stable Identifier
R-DRE-113595
Type
Set [DefinedSet]
Species
Danio rerio
Compartment
cytosol
Synonyms
ubiquitin
Locations in the PathwayBrowser
Expand all
Autophagy (Danio rerio)
Macroautophagy (Danio rerio)
Selective autophagy (Danio rerio)
Aggrephagy (Danio rerio)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Parkin transfers Ub to misfolded proteins (Danio rerio)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Mitophagy (Danio rerio)
Pink/Parkin Mediated Mitophagy (Danio rerio)
Parkin promotes the ubiquitination of mitochondrial substrates (Danio rerio)
Ub [cytosol] (Danio rerio)
Cell Cycle (Danio rerio)
Cell Cycle Checkpoints (Danio rerio)
G1/S DNA Damage Checkpoints (Danio rerio)
p53-Dependent G1/S DNA damage checkpoint (Danio rerio)
p53-Dependent G1 DNA Damage Response (Danio rerio)
Stabilization of p53 (Danio rerio)
Autodegradation of the E3 ubiquitin ligase COP1 (Danio rerio)
Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome mediated degradation of COP1 (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
p53-Independent G1/S DNA damage checkpoint (Danio rerio)
p53-Independent DNA Damage Response (Danio rerio)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Danio rerio)
Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-p-S123-CDC25A [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
G2/M Checkpoints (Danio rerio)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
Ub [cytosol] (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Anaphase (Danio rerio)
Separation of Sister Chromatids (Danio rerio)
Degradation of multiubiquitinated Securin (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)
Ub [cytosol] (Danio rerio)
Mitotic G2-G2/M phases (Danio rerio)
G2/M Transition (Danio rerio)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Danio rerio)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF-FBXL7 ubiquitinates AURKA (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of PLK1 Activity at G2/M Transition (Danio rerio)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-p-S252,S497,T501-BORA [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
The role of GTSE1 in G2/M progression after G2 checkpoint (Danio rerio)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of mitotic cell cycle (Danio rerio)
APC/C-mediated degradation of cell cycle proteins (Danio rerio)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated Skp2:phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of multiubiquitinated cell cycle proteins (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
APC/C:Cdc20 mediated degradation of Cyclin B (Danio rerio)
Degradation of multiubiquitinated Cyclin B (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
APC/C:Cdc20 mediated degradation of Securin (Danio rerio)
Degradation of multiubiquitinated Securin (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)
Ub [cytosol] (Danio rerio)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Danio rerio)
APC-Cdc20 mediated degradation of Nek2A (Danio rerio)
Degradation of multiubiquitinated Nek2A (Danio rerio)
Multiubiquitinated Nek2A [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Multiubiquitination of Nek2A (Danio rerio)
Multiubiquitinated Nek2A [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Danio rerio)
Degradation multiubiquitinated Cyclin A (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)
Ub [cytosol] (Danio rerio)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
SCF-beta-TrCP mediated degradation of Emi1 (Danio rerio)
SCF-mediated degradation of Emi1 (Danio rerio)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
S Phase (Danio rerio)
Synthesis of DNA (Danio rerio)
Switching of origins to a post-replicative state (Danio rerio)
CDK-mediated phosphorylation and removal of Cdc6 (Danio rerio)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Orc1 removal from chromatin (Danio rerio)
Ubiquitinated Orc1 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin-dependent degradation of Cyclin D (Danio rerio)
Proteasome mediated degradation of Cyclin D1 (Danio rerio)
Ub [cytosol] (Danio rerio)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Cellular responses to external stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to hypoxia (Danio rerio)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Danio rerio)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Danio rerio)
UBE2D1,2,3:Ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome proteolyzes ub-HIF-alpha (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
DNA Replication (Danio rerio)
DNA Replication Pre-Initiation (Danio rerio)
Assembly of the pre-replicative complex (Danio rerio)
CDT1 association with the CDC6:ORC:origin complex (Danio rerio)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Danio rerio)
Ub [cytosol] (Danio rerio)
geminin:ubiquitin complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated geminin is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
geminin:ubiquitin complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Synthesis of DNA (Danio rerio)
Switching of origins to a post-replicative state (Danio rerio)
CDK-mediated phosphorylation and removal of Cdc6 (Danio rerio)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Orc1 removal from chromatin (Danio rerio)
Ubiquitinated Orc1 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Developmental Biology (Danio rerio)
Axon guidance (Danio rerio)
Signaling by ROBO receptors (Danio rerio)
Regulation of expression of SLITs and ROBOs (Danio rerio)
USP33 deubiquitinates ROBO1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Danio rerio)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Danio rerio)
USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)
Ub-SMAD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD4:USP9X [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD4:USP9X [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Danio rerio)
Ub-SMAD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Transcriptional regulation by RUNX1 (Danio rerio)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Danio rerio)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)
Ub [cytosol] (Danio rerio)
ITCH polyubiquitinates TP73 (Danio rerio)
Ub [cytosol] (Danio rerio)
Transcriptional regulation by RUNX2 (Danio rerio)
Regulation of RUNX2 expression and activity (Danio rerio)
STUB1 polyubiquitinates RUNX2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Transcriptional regulation by RUNX3 (Danio rerio)
Regulation of RUNX3 expression and activity (Danio rerio)
Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
E1 mediated ubiquitin activation (Danio rerio)
E1 bound ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Polyubiquitination of substrate (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
Ub:substrate [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasomal cleavage of substrate (Danio rerio)
Ub [cytosol] (Danio rerio)
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
Ub:substrate [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Transfer of ubiquitin from E1 to E2 (Danio rerio)
E1 bound ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Downstream signaling events of B Cell Receptor (BCR) (Danio rerio)
Activation of NF-kappaB in B cells (Danio rerio)
SCF-beta-TrCP ubiquitinylates IkB (Danio rerio)
Ub [cytosol] (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
FLT3 Signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
BRAP autoubiquitinates (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of RAS by GAPs (Danio rerio)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-1 family signaling (Danio rerio)
Interleukin-1 signaling (Danio rerio)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Danio rerio)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Danio rerio)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Interleukin-17 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
TNFR2 non-canonical NF-kB pathway (Danio rerio)
NIK-->noncanonical NF-kB signaling (Danio rerio)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Danio rerio)
Ub [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Alpha-protein kinase 1 signaling pathway (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Danio rerio)
Ub [cytosol] (Danio rerio)
C-type lectin receptors (CLRs) (Danio rerio)
CLEC7A (Dectin-1) signaling (Danio rerio)
Dectin-1 mediated noncanonical NF-kB signaling (Danio rerio)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Danio rerio)
Ub [cytosol] (Danio rerio)
Cytosolic sensors of pathogen-associated DNA (Danio rerio)
Regulation of innate immune responses to cytosolic DNA (Danio rerio)
DDX41 ubiquitination by TRIM21 (Danio rerio)
Ub [cytosol] (Danio rerio)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Danio rerio)
Ub [cytosol] (Danio rerio)
STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
IRAK2 mediated activation of TAK1 complex (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
IRAK2 mediated activation of TAK1 complex (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
IRAK2 mediated activation of TAK1 complex (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF(TICAM1)-mediated TLR4 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Danio rerio)
Ub [cytosol] (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
IRAK2 mediated activation of TAK1 complex (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
IRAK2 mediated activation of TAK1 complex (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Danio rerio)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Danio rerio)
Ub [cytosol] (Danio rerio)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Danio rerio)
Ub [cytosol] (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Metabolism of RNA (Danio rerio)
Regulation of mRNA stability by proteins that bind AU-rich elements (Danio rerio)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Danio rerio)
AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)
Ub [cytosol] (Danio rerio)
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Danio rerio)
Calnexin/calreticulin cycle (Danio rerio)
ER Quality Control Compartment (ERQC) (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Danio rerio)
Ub [cytosol] (Danio rerio)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Deubiquitination (Danio rerio)
Ovarian tumor domain proteases (Danio rerio)
OTUD7A hydrolyses K11diUb (Danio rerio)
Ub [cytosol] (Danio rerio)
UCH proteinases (Danio rerio)
UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)
UCHL1,UCHL3:Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-specific processing proteases (Danio rerio)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
Ub [cytosol] (Danio rerio)
USP34 deubiquitinates AXIN1,AXIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
USP5 cleaves polyubiquitin (Danio rerio)
USP5:Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
USP8 deubiquitinates STAM2:HGS (Danio rerio)
Ub [cytosol] (Danio rerio)
USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)
Ub-SMAD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD4:USP9X [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD4:USP9X [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Neddylation (Danio rerio)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)
UBE2D1,2,3:Ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Protein ubiquitination (Danio rerio)
E3 ubiquitin ligases ubiquitinate target proteins (Danio rerio)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Danio rerio)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Danio rerio)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:PEX5L [peroxisomal membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Danio rerio)
RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Danio rerio)
Ub:UBE2L3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2L3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF144A polyubiquitinates PRKDC (Danio rerio)
RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Danio rerio)
Ub:UBE2L3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2L3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF152 polyubiquitinates RRAGA (Danio rerio)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Danio rerio)
UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
Ub [cytosol] (Danio rerio)
UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:E2 (UBA1 substrate) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)
Ub-Cys625-UBA6:ubiquitin adenylate [cytosol] (Danio rerio)
Ub-Cys625-UBA6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:E2 (UBA6 substrate) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Protein localization (Danio rerio)
Peroxisomal protein import (Danio rerio)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Danio rerio)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Danio rerio)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Danio rerio)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:PEX5L [peroxisomal membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Danio rerio)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:UBE2D1,2,3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Danio rerio)
Ub:PEX5L [peroxisomal membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
USP9X binds Ub:PEX5L (Danio rerio)
USP9X:Ub:PEX5L [cytosol] (Danio rerio)
Ub:PEX5L [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:PEX5L [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Danio rerio)
USP9X:Ub:PEX5L [cytosol] (Danio rerio)
Ub:PEX5L [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Death Receptor Signalling (Danio rerio)
TNF signaling (Danio rerio)
Regulation of TNFR1 signaling (Danio rerio)
RIPK1 is deubiquitinated (Danio rerio)
Ub [cytosol] (Danio rerio)
p75 NTR receptor-mediated signalling (Danio rerio)
Cell death signalling via NRAGE, NRIF and NADE (Danio rerio)
NRIF signals cell death from the nucleus (Danio rerio)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Danio rerio)
Ubiquitinated NRIF [cytosol] (Danio rerio)
K63 linked polyubiquitin chain [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated NRIF:Sequestosome [cytosol] (Danio rerio)
K63 linked polyubiquitin chain [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Polyubiquitinated NRIF migrates to the nucleus (Danio rerio)
Ubiquitinated NRIF:Sequestosome [cytosol] (Danio rerio)
K63 linked polyubiquitin chain [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
TRAF6 polyubiquitinates NRIF (Danio rerio)
K63 linked polyubiquitin chain [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated NRIF [cytosol] (Danio rerio)
K63 linked polyubiquitin chain [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
p75NTR signals via NF-kB (Danio rerio)
NF-kB is activated and signals survival (Danio rerio)
IkB is ubiquitinated and degraded (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated phospho-IkB [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
p75NTR recruits signalling complexes (Danio rerio)
TRAF6 is auto-ubiquitinated (Danio rerio)
Ub [cytosol] (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
PTEN Regulation (Danio rerio)
Regulation of PTEN localization (Danio rerio)
PTEN undergoes monoubiquitination (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of PTEN stability and activity (Danio rerio)
MKRN1 polyubiquitinates PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome degrades polyubiquitinated PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF146 polyubiquitinates PARylated PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
TRIM27 polyubiquitinates PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
BRAP autoubiquitinates (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of RAS by GAPs (Danio rerio)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)
Ub [cytosol] (Danio rerio)
MAPK6/MAPK4 signaling (Danio rerio)
MAPK6 is degraded by the 26S proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Hedgehog (Danio rerio)
Hedgehog 'off' state (Danio rerio)
Degradation of GLI1 by the proteasome (Danio rerio)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Danio rerio)
Ub [cytosol] (Danio rerio)
GLI3 is processed to GLI3R by the proteasome (Danio rerio)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)
Ub [cytosol] (Danio rerio)
Hedgehog 'on' state (Danio rerio)
NUMB:ITCH ubiquitinates GLI1 (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-GLI is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Hedgehog ligand biogenesis (Danio rerio)
Hh C-terminal fragments are degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by NOTCH (Danio rerio)
Signaling by NOTCH1 (Danio rerio)
Activated NOTCH1 Transmits Signal to the Nucleus (Danio rerio)
ITCH ubiquitinates DTX (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-DTX:ITCH [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
Signaling by PTK6 (Danio rerio)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Danio rerio)
CBL autoubiquitinates (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
EGFR downregulation (Danio rerio)
CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
CBL ubiquitinates Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
CBL-mediated ubiquitination of CIN85 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Downregulation of ERBB2 signaling (Danio rerio)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
CUL5 mediates ubiquitination of ERBB2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Downregulation of ERBB2:ERBB3 signaling (Danio rerio)
Deubiquitination of RNF41 by P-USP8 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-RNF41:p-USP8 [cytosol] (Danio rerio)
Ub-RNF41 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF41 ubiquitinates ERBB3 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB3 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF41 ubiquitinates activated ERBB3 (Danio rerio)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Self-ubiquitination of RNF41 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-RNF41 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated RNF41 binds P-USP8 (Danio rerio)
Ub-RNF41 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-RNF41:p-USP8 [cytosol] (Danio rerio)
Ub-RNF41 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by ERBB4 (Danio rerio)
Downregulation of ERBB4 signaling (Danio rerio)
ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Negative regulation of FGFR1 signaling (Danio rerio)
CBL ubiquitinates FRS2 and FGFR1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR2 (Danio rerio)
Negative regulation of FGFR2 signaling (Danio rerio)
CBL ubiquitinates FRS2 and FGFR2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Negative regulation of FGFR3 signaling (Danio rerio)
CBL ubiquitinates FRS2 and FGFR3 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR4 (Danio rerio)
Negative regulation of FGFR4 signaling (Danio rerio)
CBL ubiquitinates FRS2 and FGFR4 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by MET (Danio rerio)
Negative regulation of MET activity (Danio rerio)
CBL monoubiquitinates activated MET (Danio rerio)
Ub [cytosol] (Danio rerio)
USP8 deubiquitinates LRIG1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by TGF-beta family members (Danio rerio)
Signaling by TGF-beta Receptor Complex (Danio rerio)
TGF-beta receptor signaling activates SMADs (Danio rerio)
Downregulation of TGF-beta receptor signaling (Danio rerio)
Degradation of TGF-beta receptor complex (Danio rerio)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of ubiquitinated SMAD2 (Danio rerio)
Ub-SMAD2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of ubiquitinated SMAD3 (Danio rerio)
Ub-SMAD3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
SMURF2 ubiquitinates SMAD2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
STUB1 (CHIP) ubiquitinates SMAD3 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Danio rerio)
Disassembly of tight junctions (Danio rerio)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Danio rerio)
Ub [cytosol] (Danio rerio)
SMURF1 ubiquitinates RHOA (Danio rerio)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Danio rerio)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Danio rerio)
USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)
Ub-SMAD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD4:USP9X [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD4:USP9X [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Danio rerio)
Ub-SMAD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
PCP/CE pathway (Danio rerio)
Asymmetric localization of PCP proteins (Danio rerio)
SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of beta-catenin by the destruction complex (Danio rerio)
Degradation of ubiquitinated beta catenin by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
TCF dependent signaling in response to WNT (Danio rerio)
Degradation of AXIN (Danio rerio)
AXIN is ubiquitinated by SMURF2 (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF146 ubiquitinates ADP-ribosylated AXIN (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-RibC-AXIN is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of DVL (Danio rerio)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)
Ub [cytosol] (Danio rerio)
DVL1 is ubiquitinated by HECW1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated DVL is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of FZD by ubiquitination (Danio rerio)
ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)
Ub [cytosol] (Danio rerio)
ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)
Ub [cytosol] (Danio rerio)
USP34 deubiquitinates AXIN1,AXIN2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
misfolded CFTR is degraded by the 26S proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Iron uptake and transport (Danio rerio)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
Clathrin-mediated endocytosis (Danio rerio)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
BAR domain proteins recruit dynamin (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
Epsin family proteins bind ubiquitinated cargo (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Clathrin recruits PIK3C2A (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Dissociation of clathrin-associated proteins (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
RAB5 and GAPVD1 bind AP-2 (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
CLASP proteins:cargo [plasma membrane] (Danio rerio)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
ubiquitinated cargo [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Participants
members
Homologues of RPS27A(1-76) [cytosol] (Danio rerio)
RPS27A(1-76) [cytosol] (Danio rerio)
UBB(1-76) [cytosol] (Danio rerio)
UBB(77-152) [cytosol] (Danio rerio)
UBB(153-228) [cytosol] (Danio rerio)
UBC(1-76) [cytosol] (Danio rerio)
UBC(77-152) [cytosol] (Danio rerio)
UBC(153-228) [cytosol] (Danio rerio)
UBC(229-304) [cytosol] (Danio rerio)
UBC(305-380) [cytosol] (Danio rerio)
UBC(381-456) [cytosol] (Danio rerio)
UBC(457-532) [cytosol] (Danio rerio)
UBC(533-608) [cytosol] (Danio rerio)
UBC(609-684) [cytosol] (Danio rerio)
Participant Of
hasComponent
E1 bound ubiquitin [cytosol]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
geminin:ubiquitin complex [cytosol]
K63 linked polyubiquitin chain [cytosol]
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol]
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol]
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol]
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol]
Multiubiquitinated Nek2A [cytosol]
multiubiquitinated Skp2:phospho-APC/C:Cdh1 complex [cytosol]
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol]
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane]
SCF-associated multiubiquitinated Emi1complexes [cytosol]
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane]
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction]
Ub-(Y55/Y227)p-SPRY2 [plasma membrane]
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane]
Ub-Beta-Pix:CDC42:GTP [cytosol]
Ub-Cys625-UBA6 [cytosol]
Ub-Cys632-UBA1 [cytosol]
Ub-DTX:ITCH [cytosol]
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane]
Ub-ERBB3 [plasma membrane]
Ub-ERBB4:WWP1/ITCH [plasma membrane]
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol]
ub-hydroxyPro-HIF-alpha [cytosol]
Ub-misfolded nascent CFTR [cytosol]
Ub-p-S123-CDC25A [cytosol]
Ub-p-S252,S497,T501-BORA [cytosol]
Ub-p-Y53/55-SPRY1/2 [cytosol]
Ub-RNF41 [cytosol]
Ub-SMAD2 [cytosol]
Ub-SMAD3 [cytosol]
Ub-SMAD4 [cytosol]
Ub-SMAD4:USP9X [cytosol]
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]
Ub:E2 (UBA1 substrate) [cytosol]
Ub:E2 (UBA6 substrate) [cytosol]
Ub:PEX5L [cytosol]
Ub:PEX5L [peroxisomal membrane]
Ub:substrate [cytosol]
Ub:UBE2D1,2,3 [cytosol]
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol]
Ub:UBE2L3 [cytosol]
Ub:UBE2N [cytosol]
Ub:UBE2N:UBE2V1 [cytosol]
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane]
UBE2D1,2,3:Ubiquitin [cytosol]
Ubiquitin:E2 conjugating enzymes [cytosol]
ubiquitinated Cdc6 [cytosol]
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol]
ubiquitinated phospho-COP1(ser-387) [cytosol]
Ubiquitinated phospho-IkB [cytosol]
UCHL1,UCHL3:Ub [cytosol]
USP5:Ub [cytosol]
input
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
Activated TRAF6 synthesizes unanchored polyubiquitin chains
AUF1 (hnRNP D0) is ubiquitinylated
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
Autoubiquitination of phospho-COP1(Ser-387 )
AXIN is ubiquitinated by SMURF2
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
BRAP autoubiquitinates
CBL autoubiquitinates
CBL binds and ubiquitinates phosphorylated Sprouty
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
CBL monoubiquitinates activated MET
CBL ubiquitinates FRS2 and FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
CBL ubiquitinates Sprouty
CBL-mediated ubiquitination of CIN85
CHIP (STUB1) mediates ubiquitination of ERBB2
CUL5 mediates ubiquitination of ERBB2
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
DDX41 ubiquitination by TRIM21
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
DVL is ubiquitinated by CUL3:KLHL12:RBX1
DVL1 is ubiquitinated by HECW1
E1 mediated ubiquitin activation
ERBB4 ubiquitination by WWP1/ITCH
IkB is ubiquitinated and degraded
ITCH polyubiquitinates TP73
ITCH ubiquitinates DTX
KBTBD7:CUL3:RBX1 ubiquitinates NF1
MKRN1 polyubiquitinates PTEN
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
Multiubiquitination of Nek2A
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
NUMB:ITCH ubiquitinates GLI1
Parkin promotes the ubiquitination of mitochondrial substrates
Phosphorylated SPRY2 is ubiquitinated by CBL
PTEN undergoes monoubiquitination
RNF146 polyubiquitinates PARylated PTEN
RNF146 ubiquitinates ADP-ribosylated AXIN
RNF41 ubiquitinates activated ERBB3
RNF41 ubiquitinates ERBB3
RNF5 and RNF185 ubiquitinate misfolded CFTR
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
SCF(beta-TrCP) ubiquitinates p-GLI1
SCF(beta-TrCP) ubiquitinates p-GLI3
SCF-beta-TrCP ubiquitinylates IkB
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
SCF-FBXL18 ubiquitinates FBXL7
SCF-FBXL7 ubiquitinates AURKA
Self-ubiquitination of RNF41
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
SMURF1 ubiquitinates RHOA
SMURF1/2 ubiquitinates PRICKLE1
SMURF2 ubiquitinates SMAD2
STING ubiquitination by TRIM32 or TRIM56
STUB1 (CHIP) ubiquitinates SMAD3
STUB1 polyubiquitinates RUNX2
SYVN1 ubiquitinates Hh C-terminal fragments
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
TRAF6 is auto-ubiquitinated
TRIM27 polyubiquitinates PTEN
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol
UBA1 adenylates ubiquitin in the cytosol
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
Ubiquitination of Cyclin A by APC/C:Cdc20 complex
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Ubiquitination of Emi1 by SCF-beta-TrCP
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
Ubiquitination of stimulated EGFR (CBL)
Ubiquitination of stimulated EGFR (CBL:GRB2)
ZNRF3 autoubiquitinates to promote its internalization
ZNRF3 ubiquitinates FZD to promote its downregulation
output
26S proteasome degrades TP73 polyubiquitinated by ITCH
26S proteasome processes p-7S-p100:RELB to form p52:RELB
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
APC/C:Cdh1-mediated degradation of Skp2
Degradation multiubiquitinated Cyclin A
Degradation of multiubiquitinated cell cycle proteins
Degradation of multiubiquitinated Cyclin B
Degradation of multiubiquitinated Nek2A
Degradation of multiubiquitinated Securin
Degradation of ubiquitinated beta catenin by the proteasome
Deubiquitination of RNF41 by P-USP8
GTSE1 facilitates proteasome-mediated degradation of TP53
Hh C-terminal fragments are degraded by the proteasome
MAPK6 is degraded by the 26S proteasome
misfolded CFTR is degraded by the 26S proteasome
OTUD7A hydrolyses K11diUb
Polyubiquitinated RUNX3 is degraded by the proteasome
Proteasomal cleavage of substrate
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
Proteasome degrades polyubiquitinated PTEN
Proteasome mediated degradation of COP1
Proteasome mediated degradation of Cyclin D1
Proteasome proteolyzes ub-HIF-alpha
Proteasome-mediated degradation of PolyUb-FBXL7
Proteolytic degradation of ubiquitinated-Cdc25A
RIPK1 is deubiquitinated
SCF-mediated degradation of Emi1
ub-GLI is degraded by the proteasome
Ub-RibC-AXIN is degraded by the proteasome
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
Ubiquitinated AXIN is degraded by the proteasome
Ubiquitinated Cdc6 is degraded by the proteasome
Ubiquitinated DVL is degraded by the proteasome
Ubiquitinated DVL1 is degraded by the proteasome
Ubiquitinated geminin is degraded by the proteasome
Ubiquitinated Orc1 is degraded by the proteasome
USP13 and OTUD3 deubiquitinate PTEN
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
USP33 deubiquitinates ROBO1
USP34 deubiquitinates AXIN1,AXIN2
USP5 cleaves polyubiquitin
USP8 deubiquitinates LRIG1
USP8 deubiquitinates STAM2:HGS
USP9X (FAM) deubiquitinates SMAD4
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin
Inferred From
Ub [cytosol] (Homo sapiens)
© 2019
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