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Skp2 [nucleoplasm]
Stable Identifier
R-DME-975554
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
SKP2, Q7YZ95
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Regulation of BACH1 activity (Drosophila melanogaster)
BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
Regulation of RUNX2 expression and activity (Drosophila melanogaster)
SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)
RUNX2:SCF(SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)
RUNX2:SCF(SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP13 binds UFD1L:SKP2 (Drosophila melanogaster)
UFD1L:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
USP13:UFD1L:SKP2 [nucleoplasm] (Drosophila melanogaster)
UFD1L:SKP2 [nucleoplasm] (Drosophila melanogaster)
Skp2 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q7YZ95
Gene Names
Skp2
Reference Genes
BioGPS Gene:40548 Skp2
ENSEMBL:FBgn0037236
Flybase:FBgn0037236
KEGG Gene (Drosophila melanogaster):Dmel_CG9772 Skp2
Monarch:40548 Skp2
NCBI Gene:40548 Skp2
UCSC:Q7YZ95 Skp2
Reference Transcript
RefSeq:NM_164340.4 Skp2
RefSeq:NM_164341.4 Skp2
Other Identifiers
153298_at
1637091_a_at
40548
GO:0000278
GO:0003824
GO:0005515
GO:0007113
GO:0016301
GO:0016310
GO:0016740
GO:0019005
GO:0030163
GO:0031146
GO:0031647
GO:0035220
GO:0045787
GO:0048749
GO:0048856
Participates
as a component of
UFD1L:SKP2 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
Skp2 [nucleoplasm]
Skp2 [cytosol]
Skp2 [cytosol]
Skp2 [nucleoplasm]
Inferred From
SKP2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_730815.2
,
NP_730816.3
Flybase
FBgn0037236
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O77430 skpA
3
SKPA [cytosol]
(R-DME-205785)
SkpA [nucleoplasm]
(R-DME-187538)
SkpA [cytosol]
(R-DME-174150)
0.553
2
UniProt:Q9VHN1 Q9VHN1
0.553
3
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