Reactome | Mrp5 [clathrin-coated endocytic vesicle membrane]

Mrp5 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DME-8869104

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

PolyUb-CFTR, A0A0B4KGI0

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Mrp5 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Mrp5 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Mrp5 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Mrp5 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Mrp5 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Mrp5 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A0A0B4KGI0

Gene Names

Mrp5

Reference Genes

BioGPS Gene:42362 Mrp5

ENSEMBL:FBgn0038740

Flybase:FBgn0038740

Monarch:42362 Mrp5

NCBI Gene:42362 Mrp5

Reference Transcript

RefSeq:NM_001275818.1 Mrp5

Other Identifiers

150223_at

1625778_at

42362

GO:0000166

GO:0003824

GO:0005215

GO:0005524

GO:0005886

GO:0015439

GO:0016020

GO:0016787

GO:0016887

GO:0035351

GO:0042626

GO:0055085

GO:0097037

GO:0140359

GO:0140657

Participates

as a member of

Homologues of PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Other forms of this molecule

Mrp5 [plasma membrane]

Mrp5 [endoplasmic reticulum membrane]

Inferred From

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001262747.1

Flybase

FBgn0038740

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