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phospho-p-S365,S445,S729 BRAF [cytosol]
Stable Identifier
R-DME-5672667
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P11346
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
FLT3 Signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
PAQR3 binds inactive RAFs (Drosophila melanogaster)
PAQR3:inactive RAFs [Golgi membrane] (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
RAF activation (Drosophila melanogaster)
Inactive RAFs bind YWHAB (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
inactive RAFs:YWHAB dimer [cytosol] (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
PAQR3 binds inactive RAFs (Drosophila melanogaster)
PAQR3:inactive RAFs [Golgi membrane] (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
RAF activation (Drosophila melanogaster)
Inactive RAFs bind YWHAB (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
inactive RAFs:YWHAB dimer [cytosol] (Drosophila melanogaster)
inactive RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S365,S445,S729 BRAF [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P11346 Raf
Gene Names
Raf, ph, phl, CG2845
Chain
chain:1-739
Reference Genes
BioGPS Gene:31221 Raf
dbSNP Gene:31221 Raf
KEGG Gene (Drosophila melanogaster):Dmel_CG2845 Raf
Monarch:31221 Raf
NCBI Gene:31221 Raf
UCSC:P11346 Raf
Reference Transcript
RefSeq:NM_080308.4 Raf
RefSeq:NM_001103397.3 Raf
Other Identifiers
143302_at
1627470_at
AAF45774.1
AAN17541.1
AAN17542.1
AAN17543.1
AAN17544.1
AAN17545.1
AAN17546.1
AAN17547.1
AAN17548.1
AAN17549.1
AAN17550.1
AAN17551.1
AAN17552.1
AAN17553.1
AAN17554.1
AAN17555.1
AAN17556.1
AAN17557.1
AAN17558.1
AAN17559.1
AAN17560.1
AAN17561.1
AAN17562.1
ABW09328.3
AY089490
CAA30166.1
CAB72239.1
EntrezGene:31221
FBgn0003079
FBpp0070385
FBpp0310458
FBtr0070401
FBtr0344007
GO:0000003
GO:0000165
GO:0000166
GO:0000186
GO:0002168
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006914
GO:0006950
GO:0007165
GO:0007173
GO:0007265
GO:0007283
GO:0007298
GO:0007362
GO:0007369
GO:0007428
GO:0007430
GO:0007465
GO:0007472
GO:0007474
GO:0007476
GO:0007552
GO:0007623
GO:0008069
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008293
GO:0008543
GO:0008586
GO:0009056
GO:0009267
GO:0009790
GO:0016242
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0022607
GO:0030097
GO:0030154
GO:0030641
GO:0031434
GO:0035171
GO:0035309
GO:0035556
GO:0040007
GO:0040011
GO:0040014
GO:0042051
GO:0042386
GO:0042461
GO:0042592
GO:0043167
GO:0045500
GO:0046530
GO:0046534
GO:0046777
GO:0046843
GO:0046872
GO:0048010
GO:0048646
GO:0048856
GO:0048870
GO:0070371
GO:0070374
GO:2001234
IPR000719
IPR001245
IPR002219
IPR003116
IPR008271
IPR011009
IPR017441
IPR029071
M16598
NM_001103397.3
NM_080308.4
NP_001096867.3
NP_525047.1
NR_047740.1
NR_047741.1
NR_047742.1
NR_047743.1
PF00130
PF02196
PF07714
SM00109
SM00220
SM00455
UPI00000810D1
Participant Of
hasMember
inactive RAFs [cytosol]
Other forms of this molecule
Phospho PHL [plasma membrane]
PHL [cytosol]
RAF1 [cytosol]
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
phospho-p-S338-RAF1 [cytosol]
BRAF [cytosol]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-S214,S576 ARAF [cytosol]
phospho-p-S621-RAF1 [plasma membrane]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-hyperphosphorylated RAF1 [plasma membrane]
Ub-209-RIPK2 [cytosol]
RIPK2 [cytosol]
phospho-p-S299,S302,T452,T455,S576 ARAF [cytosol]
phospho-p-S445,T599,S602,S729 BRAF [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
phospho-p-S445,S729-BRAF [cytosol]
phospho-p-S445,T599,S602,S729 BRAF [plasma membrane]
phospho-p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S576 ARAF [cytosol]
phospho-p-S621-RAF1 [cytosol]
phospho-hyperphosphorylated BRAF [plasma membrane]
Inferred From
p-S365,S445,S729 BRAF [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 365 (in Homo sapiens)
Coordinate
365
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 445 (in Homo sapiens)
Coordinate
445
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729 (in Homo sapiens)
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001096867.3
,
NP_525047.1
Flybase
FBgn0003079
PRO
P11346
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24324 Dsor1
9
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
(R-DME-5674490)
DSOR1 [cytosol]
(R-DME-205968)
phospho-p-S,T-MAP2K2 [cytosol]
(R-DME-109848)
MAP2K2 [cytosol]
(R-DME-59504)
phospho-p-S222,S226-MAP2K2 [cytosol]
(R-DME-169292)
phospho-p-T286,T292-MAP2K1 [cytosol]
(R-DME-112374)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-DME-112339)
MAP2K1 [cytosol]
(R-DME-59502)
phospho-p-S218,S222-MAP2K1 [cytosol]
(R-DME-109837)
0.667
5
UniProt:P00528 SRC64
0.544
3
UniProt:P08646 Ras85D
6
RAS85D [plasma membrane]
(R-DME-205933)
NRAS [tertiary granule membrane]
(R-DME-6800190)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-DME-9647912)
S-Farn-Me-PalmS KRAS4A [plasma membrane]
(R-DME-9647915)
S-Farn-Me PalmS NRAS [plasma membrane]
(R-DME-9647910)
S-Farn-Me KRAS4B [plasma membrane]
(R-DME-9647815)
0.502
2
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