Cytosolic JET binds to and ubiquitinates CRY

Stable Identifier
R-DME-432593
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY) and ubiquitinates it, also marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.

Literature References
PubMed ID Title Journal Year
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Chen, KF, Szabo, G, Stanewsky, R

Curr Biol 2009
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Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of JET [cytosol]
Physical Entity
Activity
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Created