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CLK [nucleoplasm]
Stable Identifier
R-DME-432557
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
Transcription activation by CLK:CYC and repression by VRI (Drosophila melanogaster)
CLK and CYC bind to form a heterodimer (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
DNA:CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
Transcription regulation of cwo gene (Drosophila melanogaster)
CLK:CYC heterodimer binds to cwo gene and activates transcription (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
DNA:CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
Transcription repression by PER and activation by PDP1 (Drosophila melanogaster)
CLK is phosphorylated by DCO (Drosophila melanogaster)
Phospho TIM:DNA:CLK:CYC:Phospho (multi-site 2) PER:DCO [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
Phosphorylated PER binds to CLK (Drosophila melanogaster)
DNA:CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
Phospho TIM:DNA:CLK:CYC:Phospho (multi-site 2) PER:DCO [nucleoplasm] (Drosophila melanogaster)
CLK [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O61735 Clk
Gene Names
Clk, CLOCK, jrk, PAS1, CG7391
Chain
chain:1-1027
Reference Genes
BioGPS Gene:38872 Clk
CTD Gene:38872 Clk
KEGG Gene (Drosophila melanogaster):Dmel_CG7391 Clk
Monarch:38872 Clk
NCBI Gene:38872 Clk
UCSC:O61735 Clk
Reference Transcript
RefSeq:NM_079240.3 Clk
RefSeq:NM_001014576.2 Clk
RefSeq:NM_001014574.2 Clk
Other Identifiers
143970_at
1631948_s_at
38872
GO:0000122
GO:0000977
GO:0000978
GO:0000981
GO:0003013
GO:0003053
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0007622
GO:0007623
GO:0008062
GO:0008134
GO:0009266
GO:0009416
GO:0009649
GO:0012501
GO:0032922
GO:0043066
GO:0043226
GO:0045187
GO:0045475
GO:0045893
GO:0045944
GO:0046982
GO:0046983
GO:0048148
GO:0048511
GO:0048856
GO:0140110
GO:1990513
Participates
as an input of
CLK and CYC bind to form a heterodimer (Drosophila melanogaster)
as a component of
Phospho TIM:DNA:CLK:CYC:Phospho (multi-site 2) PER:DCO [nucleoplasm] (Drosophila melanogaster)
CLK:CYC [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
Phospho CLK [nucleoplasm]
Cross References
RefSeq
NP_001014576.1
,
NP_001014574.1
,
NP_523964.2
Flybase
FBgn0023076
PRO
O61735
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O61734 cyc
2
CYC [nucleoplasm]
(R-DME-432489)
cyc [nucleoplasm]
(R-DME-9634872)
0.75
4
UniProt:P08181 CkIIalpha
5
CKIIalpha [cytosol]
(R-DME-206181)
CSNK2A1 [nucleoplasm]
(R-DME-6805057)
CSNK2A2 [nucleoplasm]
(R-DME-6805065)
CSNK2A2 [cytosol]
(R-DME-201721)
CSNK2A1 [cytosol]
(R-DME-201713)
0.499
2
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