Cytosolic TIM is degraded by the 26S proteasome

Stable Identifier
R-DME-432507
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
16794082 JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS

Koh, K, Zheng, X, Sehgal, A

Science 2006
15178801 Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception

Busza, A, Emery-Le, M, Rosbash, M, Emery, P

Science 2004
10481010 A role for the proteasome in the light response of the timeless clock protein

Naidoo, N, Song, W, Hunter-Ensor, M, Sehgal, A

Science 1999
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Chen, KF, Szabo, G, Stanewsky, R

Curr Biol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created