JET binds to and ubiquitinates cytosolic TIM

Stable Identifier
R-DME-432401
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and TIM helps promote the interaction between the F-box domain containing protein JET with TIM. JET ubiquitinates TIM, marking it for processing by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Chen, KF, Szabo, G, Stanewsky, R

Curr Biol 2009
16794082 JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS

Koh, K, Zheng, X, Sehgal, A

Science 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of JET [cytosol]
Physical Entity
Activity
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Created