Reactome | Cytosolic PER is degraded by the 26S proteasome

Cytosolic PER is degraded by the 26S proteasome

Stable Identifier

R-DME-432361

Type

Reaction [omitted]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic PER is degraded by the 26S proteasome

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Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.

Literature References

PubMed ID	Title	Journal	Year
18593878	The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock Vanselow, JT, Edery, I, Kramer, A, Chiu, JC	Genes Dev	2008
12442174	Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime Jiang, J, Edery, I, Ko, HW	Nature	2002

Participants

Input

SLMB:UBI-P63E:Phospho (multi-site 1) PER:DCO [cytosol] (Drosophila melanogaster)

Output

Participates

as an event of

Degradation of PER (Drosophila melanogaster)

Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity

26S proteasome [cytosol] (Drosophila melanogaster)

Activity

endopeptidase activity (GO:0004175)

Authored

Williams, MG (2009-08-13)

Reviewed

Edery, I (2010-07-06)

Created

Williams, MG (2009-08-14)

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