Reactome | CBX8 [nucleoplasm]

CBX8 [nucleoplasm]

Stable Identifier

R-DME-389117

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

P26017

Locations in the PathwayBrowser

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Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX1 (Drosophila melanogaster)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Drosophila melanogaster)
        
        RUNX1 binds PRC1 complexes (Drosophila melanogaster)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4 [nucleoplasm] (Drosophila melanogaster)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Drosophila melanogaster)
        
        CBX8 [nucleoplasm] (Drosophila melanogaster)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Drosophila melanogaster)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4 [nucleoplasm] (Drosophila melanogaster)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Drosophila melanogaster)
        
        CBX8 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - PIP3 activates AKT signaling (Drosophila melanogaster)
    - PTEN Regulation (Drosophila melanogaster)
      - Regulation of PTEN gene transcription (Drosophila melanogaster)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Drosophila melanogaster)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4 [nucleoplasm] (Drosophila melanogaster)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Drosophila melanogaster)
        
        CBX8 [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4 [nucleoplasm] (Drosophila melanogaster)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Drosophila melanogaster)
        
        CBX8 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P26017

Reference Genes

BioGPS Gene:40358

ENSEMBL:FBgn0003042

Flybase:FBgn0003042

KEGG Gene (Drosophila melanogaster):Dmel_CG32443

Monarch:40358

NCBI Gene:40358

UCSC:P26017

Reference Transcript

RefSeq:NM_079475.3

Other Identifiers

143294_at

1636721_at

1PDQ

1PFB

7227.FBpp0078059

AAF51707.1

AY071619

CAA39229.1

EntrezGene:40358

FBgn0003042

FBpp0078059

FBtr0078405

GO:0000228

GO:0000278

GO:0000785

GO:0003674

GO:0003677

GO:0003682

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0005704

GO:0005725

GO:0005730

GO:0006355

GO:0006950

GO:0007049

GO:0007385

GO:0007419

GO:0008150

GO:0009058

GO:0009790

GO:0010629

GO:0016322

GO:0016458

GO:0021700

GO:0022008

GO:0030154

GO:0032991

GO:0034641

GO:0035064

GO:0035102

GO:0035186

GO:0042060

GO:0042393

GO:0043226

GO:0043565

GO:0045892

GO:0048856

GO:2001229

IPR000953

IPR016197

IPR017984

IPR023779

IPR023780

IPR033773

NM_079475.3

NP_524199.1

PF00385

PF17218

PR00504

Q541F9

SM00298

UPI0000000FD5

Participant Of

hasComponent

PRC1 complex [nucleoplasm]

hasMember

CBX2,CBX4,CBX6,CBX8 [nucleoplasm]

Inferred From

CBX8 [nucleoplasm] (Homo sapiens)

CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524199.1

Flybase

FBgn0003042

PRO

P26017

PDB

1PDQ, 1PFB