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Vinc [cytosol]
Stable Identifier
R-DME-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
VCL, O46037
Locations in the PathwayBrowser
Expand all
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
Release of platelet cytosolic components (Drosophila melanogaster)
Platelet releasate cytosolic proteins [cytosol] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Muscle contraction (Drosophila melanogaster)
Smooth Muscle Contraction (Drosophila melanogaster)
ATP Hydrolysis By Myosin (Drosophila melanogaster)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Calcium Binds Caldesmon (Drosophila melanogaster)
Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Myosin Binds ATP (Drosophila melanogaster)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Release Of ADP From Myosin (Drosophila melanogaster)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Calcium Bound Myosin Actin Complex [plasma membrane] (Drosophila melanogaster)
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
Vinc [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O46037
Gene Names
Vinc
Reference Genes
BioGPS Gene:31201 Vinc
ENSEMBL:FBgn0004397
Flybase:FBgn0004397
KEGG Gene (Drosophila melanogaster):Dmel_CG3299 Vinc
Monarch:31201 Vinc
NCBI Gene:31201 Vinc
Reference Transcript
RefSeq:NM_057472.3 Vinc
RefSeq:NM_001297884.1 Vinc
RefSeq:NM_001297885.1 Vinc
Other Identifiers
143459_at
1631535_at
31201
GO:0003779
GO:0005198
GO:0005515
GO:0005737
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0007155
GO:0008013
GO:0008092
GO:0015629
GO:0016020
GO:0043226
GO:0044291
GO:0045294
GO:0051015
GO:0070161
GO:0098592
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Drosophila melanogaster)
Vinculin bound to PIP2 [plasma membrane] (Drosophila melanogaster)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Vinc [specific granule lumen]
Vinc [secretory granule lumen]
Vinc [extracellular region]
Vinc [ficolin-1-rich granule lumen]
Inferred From
VCL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001284813.1
,
NP_001284814.1
,
NP_476820.1
Flybase
FBgn0004397
PRO
O46037
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