Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex

Stable Identifier
R-DME-209278
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
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Ubiquitinated and phosphorylated Cubitus Interruptus (CI) is processed by the proteasome complex resulting in a truncated product, CI75, with a C-terminus somewhere between residues 650-700 (Aza-Blanc et al., 1997) or 611-760 (Methot and Basler, 1999). It is thought that the zinc-finger domain and C-terminal simple sequences arrest proteasome digestion from the C-terminus. Some CI is likely to be fully proteolysed by the proteasome.

Literature References
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Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
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