SLMB binds to and ubiquitinates phosphorylated CI

Stable Identifier
R-DME-209224
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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Phosphorylated Cubitus Interruptus (CI) is now recognised by Slimb (SLMB), which is part of the SCF (Skp1, Cdc53, and F-box) ubiquitin ligase complex. CI associates with SLMB via its phosphorylated residues and is then ubiquitinated by the SCF ubiquitin ligase complex.

Literature References
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Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
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