Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'

Stable Identifier
R-DME-209094
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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The bound and phosphorylated Armadillo (ARM) is ubiquitated by the ubiquitin ligase assembled complex, whether this occurs when ARM is bound to the 'destruction complex' or after it has dissociated from it is unclear. The interaction between Slimb (SLMB) and ARM has weakened the latter's binding to the scaffolding molecules in the 'destruction complex'. ARM and the bound ubiquitin ligase assembled complex dissociate from Axin (AXN), APC (APC/APC2) and also from each other to leave free ubiquitinated and phosphorylated ARM which is now marked for degradation by the 26S proteasome.

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Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
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