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FZ2 [plasma membrane]
Stable Identifier
R-DME-205768
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Assembly of receptor complex (Drosophila melanogaster)
Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR:GISH [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
Phosphorylation of ARR (Drosophila melanogaster)
GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)
WG:FZ:ARR:GISH [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG, FZ and ARR bind to each other (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ2 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VVX3 fz2
Gene Names
fz2, CG9739
Chain
signal peptide:1-22, chain:23-694
Reference Genes
BioGPS Gene:40090 fz2
KEGG Gene (Drosophila melanogaster):Dmel_CG9739 fz2
Monarch:40090 fz2
NCBI Gene:40090 fz2
UCSC:Q9VVX3 fz2
Reference Transcript
RefSeq:NM_001104173.3 fz2
RefSeq:NM_168787.3 fz2
RefSeq:NM_001275109.1 fz2
RefSeq:NM_079431.2 fz2
RefSeq:NM_001144499.3 fz2
RefSeq:NM_001275107.1 fz2
Other Identifiers
143882_at
149033_at
1624219_s_at
1635583_s_at
40090
GO:0002376
GO:0004888
GO:0004930
GO:0005515
GO:0005634
GO:0005768
GO:0005769
GO:0005770
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007367
GO:0007435
GO:0007494
GO:0008045
GO:0008585
GO:0008587
GO:0016020
GO:0016055
GO:0016201
GO:0016477
GO:0017147
GO:0022414
GO:0023052
GO:0030154
GO:0030165
GO:0031290
GO:0031410
GO:0034330
GO:0035206
GO:0035293
GO:0035567
GO:0042685
GO:0042813
GO:0043226
GO:0048665
GO:0048675
GO:0048856
GO:0048870
GO:0050770
GO:0050808
GO:0060070
GO:0060089
GO:0060250
GO:1990851
GO:1990909
Participates
as a member of
FZ [plasma membrane] (Drosophila melanogaster)
as a component of
dFz2:dDsh [plasma membrane] (Drosophila melanogaster)
as an input of
dDsh binds dFz2 (Drosophila melanogaster)
Other forms of this molecule
fz2 [clathrin-coated endocytic vesicle membrane]
fz2 [plasma membrane]
fz2 [plasma membrane]
Cross References
RefSeq
NP_001097643.1
,
NP_001137971.1
,
NP_524155.1
,
NP_730389.1
,
NP_001262036.1
,
NP_001262038.1
Flybase
FBgn0016797
PRO
Q9VVX3
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9W450
4
Grip [cytosol]
(R-DME-416633)
Grip [cytosol]
(R-DME-416643)
Grip [plasma membrane]
(R-DME-416632)
Grip [plasma membrane]
(R-DME-416638)
0.543
3
UniProt:P19109-2 RM62
0.462
2
UniProt:Q9W237
2
RpS16 [nucleoplasm]
(R-DME-6791196)
RpS16 [cytosol]
(R-DME-72337)
0.462
2
UniProt:Q7K4L8 Q7K4L8
0.462
2
UniProt:Q04047-1 NONA
0.462
2
UniProt:Q7KVQ0
1
GAR1 [nucleoplasm]
(R-DME-6790707)
0.462
2
UniProt:P41073-1 PEP
0.462
2
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