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SkpA [nucleoplasm]
Stable Identifier
R-DME-187538
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
SKP1, O77430
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
BTRC binds p-S344, 347 NFE2L2 (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Regulation of BACH1 activity (Drosophila melanogaster)
BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
Regulation of RUNX2 expression and activity (Drosophila melanogaster)
SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)
RUNX2:SCF(SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)
RUNX2:SCF(SKP2) [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
SkpA [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O77430 skpA
Gene Names
skpA, Dredd, EG:115C2.4, CG16983, Dmel_CG16983
Reference Genes
BioGPS Gene:31016 skpA
KEGG Gene (Drosophila melanogaster):Dmel_CG16983 skpA
Monarch:31016 skpA
NCBI Gene:31016 skpA
UCSC:O77430 skpA
Reference Transcript
RefSeq:NM_001297826.1 skpA
RefSeq:NM_166857.3 skpA
RefSeq:NM_166860.3 skpA
RefSeq:NM_166856.3 skpA
RefSeq:NM_166858.3 skpA
RefSeq:NM_001038729.3 skpA
RefSeq:NM_166861.3 skpA
RefSeq:NM_166859.3 skpA
RefSeq:NM_058042.5 skpA
Other Identifiers
153376_at
1625801_s_at
31016
GO:0000278
GO:0002376
GO:0002785
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006260
GO:0006511
GO:0007010
GO:0007059
GO:0012501
GO:0016322
GO:0016567
GO:0019005
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030261
GO:0031146
GO:0031647
GO:0032436
GO:0034330
GO:0035331
GO:0036211
GO:0042023
GO:0043066
GO:0043226
GO:0045886
GO:0045931
GO:0046329
GO:0046627
GO:0048856
GO:0051298
GO:0060090
GO:0061060
GO:0090090
GO:0097602
GO:0098542
GO:0140013
GO:1905088
Participates
as a component of
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Drosophila melanogaster)
SCF (SKP2) complex [nucleoplasm] (Drosophila melanogaster)
CUL1:SKP1:SKP2 [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
SKPA [cytosol]
SkpA [cytosol]
Inferred From
SKP1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_726690.1
,
NP_726695.1
,
NP_726691.1
,
NP_001284755.1
,
NP_726692.1
,
NP_726693.1
,
NP_477390.1
,
NP_726694.1
,
NP_001033818.1
Flybase
FBgn0025637
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VDE3 Q9VDE3
0.779
6
UniProt:Q8SX86 NUTC
0.621
3
UniProt:Q9VED4 Q9VED4
0.553
2
UniProt:Q9W214 Q9W214
0.553
2
UniProt:Q9V6L9 FBSP1
0.553
2
UniProt:Q9VZF4 FBXW7
0.553
2
UniProt:Q9VKF2 Q9VKF2
0.553
2
UniProt:Q9VNX7
1
FBXL12 [cytosol]
(R-DME-8850912)
0.553
2
UniProt:Q8IGU5 Q8IGU5
0.553
2
UniProt:Q7YZ95
5
Skp2 [nucleoplasm]
(R-DME-9708570)
Skp2 [cytosol]
(R-DME-8854063)
Skp2 [cytosol]
(R-DME-975495)
Skp2 [nucleoplasm]
(R-DME-9687073)
Skp2 [nucleoplasm]
(R-DME-975554)
0.553
2
UniProt:Q24311 Cul1
4
LIN19 [cytosol]
(R-DME-206151)
Cul1 [cytosol]
(R-DME-8952519)
Cul1 [nucleoplasm]
(R-DME-187551)
Cul1 [cytosol]
(R-DME-174230)
0.534
3
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