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phospho-Shc [cytosol]
Stable Identifier
R-DME-180276
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-Y349,Y350-SHC1, Q9V3C8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
SHC1 events in EGFR signaling (Drosophila melanogaster)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
SHC1 phosphorylation by phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
SHC1 events in ERBB2 signaling (Drosophila melanogaster)
SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signaling by ERBB4 (Drosophila melanogaster)
SHC1 events in ERBB4 signaling (Drosophila melanogaster)
Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V3C8
Gene Names
Shc
Reference Genes
BioGPS Gene:44052 Shc
CTD Gene:44052 Shc
ENSEMBL:FBgn0015296
Flybase:FBgn0015296
KEGG Gene (Drosophila melanogaster):Dmel_CG3715 Shc
Monarch:44052 Shc
NCBI Gene:44052 Shc
UCSC:Q9V3C8 Shc
Reference Transcript
RefSeq:NM_079944.3 Shc
Other Identifiers
143792_at
1623967_at
44052
GO:0001751
GO:0002376
GO:0005154
GO:0005886
GO:0007163
GO:0007169
GO:0007173
GO:0007298
GO:0007362
GO:0007426
GO:0007427
GO:0007474
GO:0008069
GO:0008078
GO:0008293
GO:0008543
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030971
GO:0035011
GO:0035556
GO:0048010
GO:0048856
GO:0048870
GO:0051179
GO:0098542
GO:1904263
GO:1905815
Participates
as a component of
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [plasma membrane]
phospho-Shc [plasma membrane]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Inferred From
p-Y349,Y350-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 349 (in Homo sapiens)
Coordinate
349
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 350 (in Homo sapiens)
Coordinate
350
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_524683.2
Flybase
FBgn0015296
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VQ77 Q9VQ77
0.488
2
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