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VCP [cytosol]
Stable Identifier
R-DME-1181251
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q7KN62
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)
NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Cellular response to heat stress (Drosophila melanogaster)
HSF1 activation (Drosophila melanogaster)
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)
HDAC6:VCP:protein aggregates [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Drosophila melanogaster)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)
Deglycosylation complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ovarian tumor domain proteases (Drosophila melanogaster)
YOD1 binds VCP (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
YOD1:VCP [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)
NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RHOH GTPase cycle (Drosophila melanogaster)
RHOH binds effectors at the plasma membrane (Drosophila melanogaster)
RHOH effectors [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
RHOH:GTP:RHOH effectors [plasma membrane] (Drosophila melanogaster)
RHOH effectors [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
VCP [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q7KN62
Reference Genes
BioGPS Gene:36040
CTD Gene:36040
ENSEMBL:FBgn0286784
Flybase:FBgn0286784
KEGG Gene (Drosophila melanogaster):Dmel_CG2331
Monarch:36040
NCBI Gene:36040
UCSC:Q7KN62
Reference Transcript
RefSeq:NM_001103780.2
RefSeq:NM_058021.4
RefSeq:NM_001103779.2
Other Identifiers
153155_at
1628008_a_at
36040
GO:0000166
GO:0000226
GO:0000278
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005783
GO:0005829
GO:0005886
GO:0006508
GO:0006511
GO:0006886
GO:0006914
GO:0007010
GO:0007029
GO:0007030
GO:0007040
GO:0007279
GO:0007317
GO:0012501
GO:0016192
GO:0016320
GO:0016787
GO:0016887
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030433
GO:0030970
GO:0031593
GO:0031965
GO:0032436
GO:0034098
GO:0035096
GO:0043161
GO:0043186
GO:0043226
GO:0043523
GO:0043525
GO:0044754
GO:0045169
GO:0045879
GO:0046598
GO:0046716
GO:0048477
GO:0048813
GO:0048856
GO:0050896
GO:0051228
GO:0061024
GO:0061909
GO:0071712
GO:0090090
GO:0097212
GO:0097352
GO:0098586
GO:0140657
Participates
as a candidate of
RHOH effectors [cytosol] (Drosophila melanogaster)
as an input of
YOD1 binds VCP (Drosophila melanogaster)
as a component of
YOD1:VCP [cytosol] (Drosophila melanogaster)
HDAC6:VCP:protein aggregates [cytosol] (Drosophila melanogaster)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Drosophila melanogaster)
VCP hexamer [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Me3K315-VCP [cytosol]
VCP [nucleoplasm]
VCP [azurophil granule lumen]
VCP [secretory granule lumen]
VCP [extracellular region]
VCP [ficolin-1-rich granule lumen]
Inferred From
VCP [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001097250.1
,
NP_001097249.1
,
NP_477369.1
Flybase
FBgn0286784
PRO
Q7KN62
PDB
4RV0
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7K0S5 Q7K0S5
0.567
5
UniProt:Q7K4I5
2
Dmel\CG8892 [cytosol]
(R-DME-9755305)
Dmel\CG8892 [cytosol]
(R-DME-8956071)
0.488
2
UniProt:Q8SYH8 Q8SYH8
0.488
2
UniProt:Q0IGU0 Q0IGU0
0.488
2
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