Reactome | UPF3A [cytosol]

UPF3A [cytosol]

Stable Identifier

R-DDI-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q54DH9

Locations in the PathwayBrowser

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Metabolism of RNA (Dictyostelium discoideum)

- Nonsense-Mediated Decay (NMD) (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        UPF3 [cytosol] (Dictyostelium discoideum)
        
        UPF3A [cytosol] (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        UPF3 [cytosol] (Dictyostelium discoideum)
        
        UPF3A [cytosol] (Dictyostelium discoideum)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        UPF3 [cytosol] (Dictyostelium discoideum)
        
        UPF3A [cytosol] (Dictyostelium discoideum)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        UPF3 [cytosol] (Dictyostelium discoideum)
        
        UPF3A [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54DH9

Reference Genes

BioGPS Gene:8628577

dictyBase:DDB_G0292240

ENSEMBL:DDB_G0292240

KEGG Gene (Dictyostelium discoideum):DDB_G0292240

Monarch:8628577

NCBI Gene:8628577

Reference Transcript

RefSeq:XM_629746.1

Participates

as a component of

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Dictyostelium discoideum)

as a member of

UPF3 [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

UPF3B [nucleoplasm]

UPF3B [cytosol]

Inferred From

UPF3AS-2 [cytosol] (Homo sapiens)

UPF3A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_629748.1

PRO

Q54DH9

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