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pole2 [nucleoplasm]
Stable Identifier
R-DDI-68482
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
nucleoplasm
Synonyms
POLE2, Q54Y85
Locations in the PathwayBrowser
Expand all
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
G1/S Transition (Dictyostelium discoideum)
Activation of the pre-replicative complex (Dictyostelium discoideum)
DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
S Phase (Dictyostelium discoideum)
Synthesis of DNA (Dictyostelium discoideum)
DNA replication initiation (Dictyostelium discoideum)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA Repair (Dictyostelium discoideum)
Base Excision Repair (Dictyostelium discoideum)
Resolution of Abasic Sites (AP sites) (Dictyostelium discoideum)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Dictyostelium discoideum)
PCNA-Dependent Long Patch Base Excision Repair (Dictyostelium discoideum)
LIG1 binds APEX1 and PCNA at SSB (Dictyostelium discoideum)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
LIG1 bound to APEX1 and PCNA ligates SSB (Dictyostelium discoideum)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Dictyostelium discoideum)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE-mediated DNA strand displacement synthesis (Dictyostelium discoideum)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA Damage Bypass (Dictyostelium discoideum)
Recognition of DNA damage by PCNA-containing replication complex (Dictyostelium discoideum)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Dictyostelium discoideum)
Termination of translesion DNA synthesis (Dictyostelium discoideum)
POLD,POLE binds deISGylated PCNA after TLS (Dictyostelium discoideum)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
Nucleotide Excision Repair (Dictyostelium discoideum)
Global Genome Nucleotide Excision Repair (GG-NER) (Dictyostelium discoideum)
Gap-filling DNA repair synthesis and ligation in GG-NER (Dictyostelium discoideum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Dual incision in TC-NER (Dictyostelium discoideum)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)
POLD,POLE,POLK [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
Gap-filling DNA repair synthesis and ligation in TC-NER (Dictyostelium discoideum)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Dictyostelium discoideum)
PCNA:POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
POLD,POLE [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA Replication (Dictyostelium discoideum)
DNA Replication Pre-Initiation (Dictyostelium discoideum)
Activation of the pre-replicative complex (Dictyostelium discoideum)
DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
Synthesis of DNA (Dictyostelium discoideum)
DNA replication initiation (Dictyostelium discoideum)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon:origin complex [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
pole2 [nucleoplasm] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:Q54Y85
Gene Names
pole2
Reference Genes
BioGPS Gene:8621523 pole2
dictyBase:DDB_G0278367
ENSEMBL:DDB_G0278367
KEGG Gene (Dictyostelium discoideum):DDB_G0278367 pole2
Monarch:8621523 pole2
NCBI Gene:8621523 pole2
Reference Transcript
RefSeq:XM_637225.1 pole2
Participates
as a component of
DNA polymerase epsilon [nucleoplasm] (Dictyostelium discoideum)
Inferred From
POLE2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_642317.1
PRO
Q54Y85
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