Reactome | SPSB1 [cytosol]

SPSB1 [cytosol]

Stable Identifier

R-CFA-976024

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SPSB1, A0A8I3Q1W3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SPSB1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q1W3

Gene Names

SPSB1

Reference Genes

ENSEMBL:ENSCAFG00845028867.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028867.1 SPSB1

Other Identifiers

479598

Cfa.5549.1.A1_at

Cfa.7477.1.A1_s_at

GO:0005515

GO:0005829

GO:0006511

GO:0016567

GO:0030163

GO:0036211

GO:0060090

GO:1990756

Participates

as a member of

Inferred From

SPSB1 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000171621

Ensembl

ENSCAFG00845028867, ENSCAFT00845051030, ENSCAFP00845040006

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