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PSMC2 [cytosol]
Stable Identifier
R-CFA-68771
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
F1PPH7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
Autodegradation of the E3 ubiquitin ligase COP1 (Canis familiaris)
Proteasome mediated degradation of COP1 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Separation of Sister Chromatids (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Canis familiaris)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of Securin (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
Degradation multiubiquitinated Cyclin A (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
DNA Replication (Canis familiaris)
DNA Replication Pre-Initiation (Canis familiaris)
Assembly of the pre-replicative complex (Canis familiaris)
CDT1 association with the CDC6:ORC:origin complex (Canis familiaris)
Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX1 (Canis familiaris)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Canis familiaris)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing-Cross presentation (Canis familiaris)
Cross-presentation of soluble exogenous antigens (endosomes) (Canis familiaris)
Proteasomal clevage of exogenous antigen (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Proteasomal cleavage of substrate (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Ubiquitinated IkB is degraded (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Regulation of RAS by GAPs (Canis familiaris)
NF1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
26Sproteasome degrades K48polyUb-NIK (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of polyamines (Canis familiaris)
Regulation of ornithine decarboxylase (ODC) (Canis familiaris)
26S proteosome degrades ODC holoenzyme complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Metabolism of RNA (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Canis familiaris)
AUF1:mRNA complex is destroyed (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
UCH proteinases (Canis familiaris)
ADRM1 binds 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
ADRM1:26S proteasome:UCHL5 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
ADRM1:26S proteaseome binds USP14 (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
ADRM1:26S proteasome:USP14 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Neddylation (Canis familiaris)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
Proteasome degrades polyubiquitinated PTEN (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Regulation of RAS by GAPs (Canis familiaris)
NF1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
MAPK6 is degraded by the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
Degradation of GLI1 by the proteasome (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
GLI3 is processed to GLI3R by the proteasome (Canis familiaris)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
ub-GLI is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
Asymmetric localization of PCP proteins (Canis familiaris)
PRICKLE1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Degradation of AXIN (Canis familiaris)
Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Degradation of DVL (Canis familiaris)
Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSMC2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1PPH7
Reference Genes
BioGPS Gene:475896
dbSNP Gene:475896
ENSEMBL:ENSCAFG00000004204
KEGG Gene (Canis familiaris):475896
Monarch:475896
NCBI Gene:475896
Reference Transcript
RefSeq:XM_533103.5
Other Identifiers
475896
AAEX03011248
Cfa.281.1.S1_s_at
ENSCAFG00000004204
ENSCAFP00000006249
ENSCAFT00000006754
EntrezGene:475896
EntrezGene:PSMC2
GO:0000166
GO:0000502
GO:0003674
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0006511
GO:0008134
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0016787
GO:0016887
GO:0017025
GO:0022607
GO:0030163
GO:0032991
GO:0034641
GO:0036402
GO:0036464
GO:0043167
GO:0043197
GO:0043226
GO:0045899
GO:0065003
GO:1901800
IPR003593
IPR003959
IPR003960
IPR005937
IPR027417
IPR035245
IPR041569
PF00004
PF17862
PSMC2
PSMC2-201
SM00382
UPI000013237A
VGNC:45102
XM_533103
XP_533103
Participant Of
hasComponent
26S proteasome [cytosol]
Other forms of this molecule
PSMC2 [secretory granule lumen]
PSMC2 [extracellular region]
PSMC2 [ficolin-1-rich granule lumen]
PSMC2 [nucleoplasm]
Inferred From
PSMC2 [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_533103.3
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