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CDC6 [nucleoplasm]
Stable Identifier
R-CFA-68542
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
CDC6, A0A8I3N9L3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
Activation of ATR in response to replication stress (Canis familiaris)
Activation of claspin (Canis familiaris)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Loading of claspin onto DNA during replication origin firing (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1/S Transition (Canis familiaris)
Activation of the pre-replicative complex (Canis familiaris)
Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA polymerase alpha:primase binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA polymerase epsilon binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cdc6 protein is phosphorylated by CDK (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA Replication (Canis familiaris)
DNA Replication Pre-Initiation (Canis familiaris)
Activation of the pre-replicative complex (Canis familiaris)
Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA polymerase alpha:primase binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
DNA polymerase epsilon binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Assembly of the pre-replicative complex (Canis familiaris)
CDC6 association with the ORC:origin complex (Canis familiaris)
CDC6 association with ORC(1-6) at replication origins (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
CDC6:MCM8 [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
MCM8 binds CDC6 (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
CDC6:MCM8 [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cdc6 protein is phosphorylated by CDK (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
CDC6 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N9L3
Gene Names
CDC6
Reference Genes
ENSEMBL:ENSCAFG00845008754.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008754.1 CDC6
Other Identifiers
480527
Cfa.1437.1.S1_at
Cfa.1437.1.S1_s_at
CfaAffx.24713.1.S1_at
GO:0000278
GO:0000910
GO:0000922
GO:0003824
GO:0005524
GO:0005634
GO:0005654
GO:0005829
GO:0005856
GO:0006260
GO:0006270
GO:0007059
GO:0016787
GO:0016887
GO:0019900
GO:0030071
GO:0032467
GO:0043226
GO:0045171
GO:0051233
GO:0051301
GO:0051984
GO:0072686
GO:0140657
Participates
as an input of
Cdc6 protein is phosphorylated by CDK (Canis familiaris)
CDC6 association with ORC(1-6) at replication origins (Canis familiaris)
MCM8 binds CDC6 (Canis familiaris)
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
CDC6:MCM8 [nucleoplasm] (Canis familiaris)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Canis familiaris)
CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
Other forms of this molecule
CDC6 [cytosol]
phospho-CDC6 [cytosol]
phospho-CDC6 [nucleoplasm]
Inferred From
CDC6 [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000094804
Ensembl
ENSCAFG00845008754
,
ENSCAFP00845012021
,
ENSCAFT00845015476
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