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phospho-BRAF [plasma membrane]
Stable Identifier
R-CFA-5672679
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
p-S446,T599,S602,S729 BRAF, A0A8I3SCX1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Negative feedback regulation of MAPK pathway (Canis familiaris)
Activated MAPKs phosphorylate BRAF (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
RAF activation (Canis familiaris)
Phosphorylation of RAF (Canis familiaris)
RAF activating kinases [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
phospho-BRAF [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3SCX1
Gene Names
BRAF
Reference Genes
ENSEMBL:ENSCAFG00845031038.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845031038.1 BRAF
Other Identifiers
475526
CfaAffx.6820.1.S1_s_at
GO:0000165
GO:0000166
GO:0002318
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0005509
GO:0005524
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006468
GO:0007010
GO:0007155
GO:0007165
GO:0007173
GO:0008542
GO:0010628
GO:0010764
GO:0010828
GO:0012501
GO:0016079
GO:0016192
GO:0016740
GO:0023052
GO:0030154
GO:0030878
GO:0033077
GO:0033138
GO:0034446
GO:0035019
GO:0036211
GO:0042127
GO:0042802
GO:0043005
GO:0043066
GO:0043149
GO:0043226
GO:0043231
GO:0043367
GO:0043368
GO:0043369
GO:0043524
GO:0044297
GO:0045580
GO:0046632
GO:0046872
GO:0048538
GO:0048679
GO:0048680
GO:0048856
GO:0048870
GO:0050772
GO:0050852
GO:0050877
GO:0051496
GO:0055085
GO:0060291
GO:0060323
GO:0060324
GO:0070371
GO:0070374
GO:0070413
GO:0071277
GO:0071466
GO:0072577
GO:0090150
GO:0097110
GO:0098793
GO:0140096
GO:1900026
GO:2000301
GO:2000352
Participates
as an input of
Activated MAPKs phosphorylate BRAF (Canis familiaris)
as a candidate of
RAF activating kinases [plasma membrane] (Canis familiaris)
activated RAF/KSR1 [plasma membrane] (Canis familiaris)
Other forms of this molecule
BRAF [cytosol]
phospho-BRAF [plasma membrane]
phospho-BRAF [cytosol]
phospho-BRAF [cytosol]
phospho-BRAF [cytosol]
Inferred From
p-S446,T599,S602,S729 BRAF [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 446 (in Homo sapiens)
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729 (in Homo sapiens)
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599 (in Homo sapiens)
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602 (in Homo sapiens)
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000157764
Ensembl
ENSCAFT00845055177
,
ENSCAFG00845031038
,
ENSCAFP00845043393
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